Flexible nanoassembly for sequestering non-native proteins

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Slingsby, Christine ; Clark, Alice R. (2013)
  • Publisher: Elsevier
  • Journal: Structure (issn: 0969-2126, vol: 21, pp: 193-194)
  • Related identifiers: doi: 10.1016/j.str.2013.01.009
  • Subject: Molecular Biology | bcs | Structural Biology

A crystal structure of a yeast small heat shock protein reported by Hanazono and colleagues in this issue of Structure reveals the versatility of the α-crystallin domain dimer for building assemblies of different size and symmetry. The domains assemble into a vessel filled with hydrophobic sequence extensions enriched with phenylalanines.
  • References (7)

    Baldwin, A.J., Lioe, H., Hilton, G.R., Baker, L.A., Rubinstein, J.L., Kay, L.E., and Benesch, J.L.P. (2011). Structure 19, 1855-1863.

    Basha, E., O'Neill, H., and Vierling, E. (2012). Trends Biochem. Sci. 37, 106-117.

    Clark, A.R., Naylor, C.E., Bagne´ ris, C., Keep, N.H., and Slingsby, C. (2011). J. Mol. Biol. 408, 118-134.

    Delbecq, S.P., and Klevit, R.E. (2013). FEBS Lett. Published online January 19, 2013. http://dx.doi. org/10.1016/j.febslet.2013.01.021.

    Hanazono, Y., Takeda, K., Oka, T., Abe, T., Tomonari, T., Akiyama, N., Aikawa, Y., Yohda, M., and Mikia, K. (2013). Structure 21, this issue, 220-228.

    McHaourab, H.S., Lin, Y.L., and Spiller, B.W. (2012). Biochemistry 51, 5105-5112.

    Slingsby, C., Wistow, G.J., and Clark, A.R. (2013). Protein Sci., in press.

  • Bioentities (5)
    1gme Protein Data Bank
    1shs Protein Data Bank
    3vqk Protein Data Bank
    3w1z Protein Data Bank
    4eld Protein Data Bank
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