Impact of Chlamydia trachomatis in the reproductive setting: British Fertility Society Guidelines for practice

Article English OPEN
Akande, V. ; Turner, C. ; Horner, P. ; Horne, A. ; Pacey, A. ; Soc, B.F. (2010)
  • Publisher: Taylor & Francis

Chlamydia trachomatis infection of the genital tract is the most common sexually transmitted infection and has a world-wide distribution. The consequences of infection have an adverse effect on the reproductive health of women and are a common cause of infertility. Recent evidence also suggests an adverse effect on male reproduction. There is a need to standardise the approach in managing the impact of C. trachomatis infection on reproductive health. We have surveyed current UK practice towards screening and management of Chlamydia infections in the fertility setting. We found that at least 90% of clinicians surveyed offered screening. The literature on this topic was examined and revealed a paucity of solid evidence for estimating the risks of long-term reproductive sequelae following lower genital tract infection with C. trachomatis. The mechanism for the damage that occurs after Chlamydial infections is uncertain. However, instrumentation of the uterus in women with C. trachomatis infection is associated with a high risk of pelvic inflammatory disease, which can be prevented by appropriate antibiotic treatment and may prevent infected women from being at increased risk of the adverse sequelae, such as ectopic pregnancy and tubal factor infertility. Recommendations for practice have been proposed and the need for further studies is identified.
  • References (89)
    89 references, page 1 of 9

    1The authors gratefully acknowledge the expertise of Professor Gary Entrican (Moredun Research Institute,

    Baczynska A, Funch P, Fedder J, Knudsen HJ, Birkelund S, Christiansen G. Morphology of human Fallopian tubes after infection with Mycoplasma genitalium and Mycoplasma hominis--in vitro organ culture study. Human Reproduction. 2007; 22:968-979. [PubMed: 17158214]

    Bakken IJ, Skjeldestad FE, Nordbø SA. C. trachomatis infections increase the risk for ectopic pregnancy: a population-based, nested case-control study. Sex Transm Dis. 2007; 34:166-169. [PubMed: 16837829]

    Bakken IJ. C. trachomatis and ectopic pregnancy: recent epidemiological findings. Curr Opin Infect Dis. 2008; 21:77-82. [PubMed: 18192790]

    Beatty WL, Morrison RP, Byrne GI. Persistent chlamydiae: from cell culture to a paradigm for chlamydial pathogenesis. Microbiol Rev. 1994; 58:686-99. [PubMed: 7854252]

    Bébéar C, de Barbeyrac B. Genital C. trachomatis infections. Clin Microbiol Infect. 2009; 15:4-10.

    Bezold G, Politch JA, Kiviat NB, Kuypers JM, Wolff H, Anderson DJ. Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia. Fertility & Sterility. 2007; 87:1087-1097. [PubMed: 17433312]

    Bjartling C, Osser S, Persson K. Deoxyribonucleic acid of C. trachomatis in fresh tissue from the Fallopian tubes of patients with ectopic pregnancy. Eur J Obstet Gynecol Reprod Biol. 2007; 134:95-100. [PubMed: 17280761]

    Blackwell AL, Thomas PD, Wareham K, Emery SJ, Blackwell AL, Thomas PD, Wareham K, Emery SJ. Health gains from screening for infection of the lower genital tract in women attending for termination of pregnancy. Lancet. 1993; 342:206-210. [PubMed: 8100930]

    Broder S, Sims S, Rothman C. Frequency of postinsemination infections as reported by donor semen recipients. Fertil Steril. 2007; 88:711-713. [PubMed: 17678913]

  • Metrics
    0
    views in OpenAIRE
    0
    views in local repository
    24
    downloads in local repository

    The information is available from the following content providers:

    From Number Of Views Number Of Downloads
    White Rose Research Online - IRUS-UK 0 24
Share - Bookmark