publication . Article . 2015

Cholinergic enhancement of cell proliferation in the postnatal neurogenic niche of the mammalian

Corns, LF; Atkinson, L; Daniel, J; Edwards, IJ; New, L; Deuchars, J; Deuchars, SA;
Open Access English
  • Published: 01 Sep 2015
  • Publisher: Wiley
  • Country: United Kingdom
Abstract
The region surrounding the central canal (CC) of the spinal cord is a highly plastic area, defined as a postnatal neurogenic niche. Within this region are ependymal cells which can proliferate and differentiate to form new astrocytes and oligodendrocytes following injury and cerebrospinal fluid contacting cells (CSFcCs). The specific environmental conditions, including the modulation by neurotransmitters that influence these cells and their ability to proliferate, are unknown. Here we show that acetylcholine promotes the proliferation of ependymal cells in mice under both in vitro and in vivo conditions. Using whole cell patch clamp in acute spinal cord slices, ...
44 references, page 1 of 3

1 Pfenninger CV, Steinhoff C, Hertwig F et al. Prospectively isolated CD133/CD24- positive ependymal cells from the adult spinal cord and lateral ventricle wall differ in their long-term in vitro self-renewal and in vivo gene expression. Glia 2011;59:68-81.

2 Johansson CB, Momma S, Clarke DL et al. Identification of a neural stem cell in the adult mammalian central nervous system. Cell 1999;96:25-34. [OpenAIRE]

3 Mothe AJ, Tator CH. Proliferation, migration, and differentiation of endogenous ependymal region stem/progenitor cells following minimal spinal cord injury in the adult rat. Neuroscience 2005;131:177-187. [OpenAIRE]

4 Meletis K, Barnabe-Heider F, Carlen M et al. Spinal cord injury reveals multilineage differentiation of ependymal cells. Plos Biol 2008;6:1494-1507. [OpenAIRE]

5 Barnabe-Heider F, Goritz C, Sabelstrom H et al. Origin of new glial cells in intact and injured adult spinal cord. Cell Stem Cell 2010;7:470-482. [OpenAIRE]

6 Danilov AI, Covacu R, Moe MC et al. Neurogenesis in the adult spinal cord in an experimental model of multiple sclerosis. Eur J Neurosci 2006;23:394-400. [OpenAIRE]

7 Marichal N, Garcia G, Radmilovich M et al. Enigmatic central canal contacting cells: Immature Neurons in "standby mode"? J Neurosci 2009;29:10010-10024.

8 Stoeckel ME, Uhl-Bronner S, Hugel S et al. Cerebrospinal fluid-contacting neurons in the rat spinal cord, a gamma-aminobutyric acidergic system expressing the P2X(2) subunit of purinergic receptors, PSA-NCAM, and GAP-43 immunoreactivities: Light and electron microscopic study. J Compar Neurol 2003;457:159-174. [OpenAIRE]

9 Reimer MM, Norris A, Ohnmacht J et al. Dopamine from the brain promotes spinal motor neuron generation during development and adult regeneration. Dev cell 2013;25:478-491. [OpenAIRE]

10 Berg DA, Belnoue L, Song H et al. Neurotransmitter-mediated control of neurogenesis in the adult vertebrate brain. Development 2013;140:2548-2561. [OpenAIRE]

11 Cooper-Kuhn CM, Winkler J, Kuhn HG. Decreased neurogenesis after cholinergic forebrain lesion in the adult rat. J Neurosci Res 2004;77:155-165.

12 Kaneko N, Okano H, Sawamoto K. Role of the cholinergic system in regulating survival of newborn neurons in the adult mouse dentate gyrus and olfactory bulb. Genes Cells 2006;11:1145-1159.

13 Kotani S, Yamauchi T, Teramoto T et al. Pharmacological evidence of cholinergic involvement in adult hippocampal neurogenesis in rats. Neuroscience 2006;142:505-514.

14 Campbell NR, Fernandes CC, Halff AW et al. Endogenous signaling through alpha7- containing nicotinic receptors promotes maturation and integration of adult-born neurons in the hippocampus. J Neurosci 2010; 30:8734-8744. [OpenAIRE]

15 Paez-Gonzalez P, Asrican B, Rodriguez E et al. Identification of distinct ChAT neurons and activity-dependent control of postnatal SVZ neurogenesis. Nat Neurosci 2014. [OpenAIRE]

44 references, page 1 of 3
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue