Myoblast models of skeletal muscle hypertrophy and atrophy

Article English OPEN
Sharples, AP; Stewart, CE;

Purpose of review: To highlight recent breakthroughs and controversies in the use of myoblast models to uncover cellular and molecular mechanisms regulating skeletal muscle hypertrophy and atrophy.\ud \ud Recent findings: Myoblast cultures provide key mechanistic models... View more
  • References (58)
    58 references, page 1 of 6

    1. Amthor H, Otto A, Vulin A, Rochat A, Dumonceaux J, Garcia L, et al. Muscle hypertrophy driven by myostatin blockade does not require stem/precursor-cell activity. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7479-84.

    2. Schultz SS, Lucas PA. Human stem cells isolated from adult skeletal muscle differentiate into neural phenotypes. J Neurosci Methods. 2006 Apr 15;152(1-2):144-55.

    3. Lee KS, Kim HJ, Li QL, Chi XZ, Ueta C, Komori T, et al. Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol Cell Biol. 2000 Dec;20(23):8783-92.

    4. Katagiri T, Yamaguchi A, Komaki M, Abe E, Takahashi N, Ikeda T, et al. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol. 1994 Dec;127(6 Pt 1):1755-66.

    5. Peng H, Huard J. Muscle-derived stem cells for musculoskeletal tissue regeneration and repair. Transpl Immunol. 2004 Apr;12(3-4):311-9.

    6. Lee SJ, Lee EJ, Kim SH, Choi I, Lee DM, Lee HJ, et al. IL-17A promotes transdifferentiation of mouse myoblast cells (C2C12) into adipocytes by increasing the expression of peroxisome proliferator-activated receptor gamma through CAAT/enhancer binding protein beta signaling. Biotechnol Lett. 2010 Oct 20.

    7. Saini A, Faulkner S, Al-Shanti N, Stewart C. Powerful signals for weak muscles. Ageing Res Rev. 2009 Oct;8(4):251-67.

    8. Mudera V, Smith AS, Brady M, Lewis MP. The effect of cell density on the maturation and contractile ability of muscle derived cells in a 3D tissue-engineered skeletal muscle model and determination of the cellular and mechanical stimuli required for the synthesis of a postural phenotype. J Cell Physiol. 2010 Jun 7;225:646-53.

    9. Dennis RG, Kosnik PE, 2nd. Excitability and isometric contractile properties of mammalian skeletal muscle constructs engineered in vitro. In Vitro Cell Dev Biol Anim. 2000 May;36(5):327-35.

    10. Scime A, Rudnicki MA. Anabolic potential and regulation of the skeletal muscle satellite cell populations. Curr Opin Clin Nutr Metab Care. 2006 May;9(3):214-9.

  • Related Organizations (6)
  • Metrics
Share - Bookmark