NMR analysis of synthetic human serum albumin alpha-helix 28 identifies structural distortion upon amadori modification

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Howard, Mark J.; Smales, Christopher Mark;
(2005)

The non-enzymatic reaction between reducing sugars and long-lived proteins in vivo results in the formation of glycation and advanced glycation end products, which alter the properties of proteins including charge, helicity, and their tendency to aggregate. Such protein... View more
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