Characterisation of CXCL14 function and target cells in blood and tissues

0044 English OPEN
Collins, Paul J.;
(2016)
  • Subject: R1

The human chemokine family consists of around 50 peptides that control the migratory patterns and positioning of all leukocytes. One such member of this family is CXCL14. Very highly expressed in many healthy tissues including skin, gut and kidney, loss of CXCL14 expres... View more
  • References (38)
    38 references, page 1 of 4

    .............................................................................................................................149 Figure 4.12. None of the five orphan receptors mediate chemotaxis toward CXCL14 or binding of AF-CXCL14......................................................................................151 Figure 4.13. Small hairpin RNA-mediated gene silencing. ....................................152 Figure 4.14. Surface expression of CCR2 and the chemotactic response to CCL2 in THP-1 cells is unaffected by PGE2 treatment........................................................154 Figure 5.5. CXCL14 synergises with CXCL12 in the induction of rapid cellular responses.............................................................................................................174 Figure 5.6. CXCL14 also synergises with the CCR7 ligands CCL21 and CCL19 in the induction of chemotactic responses in primary human T cells...............................175 Figure 5.7. CXCL14 synergises with the CCR7 ligands CCL21 and CCL19 in the induction of chemotactic responses in primary human B cells...............................176 Figure 5.8. CXCL14 synergises with CCL21 and CCL19 in the induction of chemotactic responses in 300.19 cells stably transfected with CCR7. ..................177 Figure 5.9. CXCL14 synergises with the CXCR5 ligand CXCL13 on primary B cells.

    Y., MARSAL, J., ARENZANA-SEISDEDOS, F., DELAUNAY, T., EBERT, E. C., MOSER, B. & PARKER, C. M. 2000. Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation. Curr Biol, 10, 325-8.

    ALTIN, J. G. & SLOAN, E. K. 1997. The role of CD45 and CD45-associated molecules in T cell activation. Immunol Cell Biol, 75, 430-45.

    2009. Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets. BMC Genomics, 10, 403.

    2006. Cutting edge: CD1a+ antigen-presenting cells in human dermis respond rapidly to CCR7 ligands. J Immunol, 176, 5730-4.

    ARA, T., TOKOYODA, K., SUGIYAMA, T., EGAWA, T., KAWABATA, K. & NAGASAWA, T. 2003.

    Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny. Immunity, 19, 257-67.

    AUFFRAY, C., SIEWEKE, M. H. & GEISSMANN, F. 2009. Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol, 27, 669-92.

    AUGSTEN, M., HAGGLOF, C., OLSSON, E., STOLZ, C., TSAGOZIS, P., LEVCHENKO, T., FREDERICK, M. J., BORG, A., MICKE, P., EGEVAD, L. & OSTMAN, A. 2009. CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth. Proc Natl Acad Sci U S A, 106, 3414-9.

    BAGGIOLINI, M., WALZ, A. & KUNKEL, S. L. 1989. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J Clin Invest, 84, 1045-9.

  • Related Research Results (1)
  • Metrics
Share - Bookmark