publication . Other literature type . Article . 2019

Fornix white matter glia damage causes hippocampal gray matter damage during age-dependent limbic decline

Claudia Metzler-Baddeley; Jilu P. Mole; Rebecca Sims; Fabrizio Fasano; John Evans; Derek K. Jones; John P. Aggleton; Roland J. Baddeley;
Open Access
  • Published: 31 Jan 2019
  • Publisher: Springer Science and Business Media LLC
  • Country: United Kingdom
Abstract
Abstract Aging leads to gray and white matter decline but their causation remains unclear. We explored two classes of models of age and dementia risk related brain changes. The first class of models emphasises the importance of gray matter: age and risk-related processes cause neurodegeneration and this causes damage in associated white matter tracts. The second class of models reverses the direction of causation: aging and risk factors cause white matter damage and this leads to gray matter damage. We compared these models with linear mediation analysis and quantitative MRI indices (from diffusion, quantitative magnetization transfer and relaxometry imaging) of...
Subjects
Medical Subject Headings: nervous system
free text keywords: /dk/atira/pure/core/keywords/cognitive_science, Cognitive Science, /dk/atira/pure/core/keywords/visual_perception, Visual Perception, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428, Journal Article, /dk/atira/pure/researchoutput/pubmedpublicationtype/D013485, Research Support, Non-U.S. Gov't, Medicine, R, Science, Q, Article, Multidisciplinary
Funded by
WT| Tractometry.
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 096646
  • Funding stream: Neuroscience and Mental Health
,
WT| Multi-scale and multi-modal assessment of coupling in the healthy and diseased brain.
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 104943
  • Funding stream: Cognitive Neuroscience and Mental Health
,
WT
Project
  • Funder: Wellcome Trust (WT)
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