publication . Thesis

The mechanism of racemisation of 5-substituted hydantoins in aqueous solution

Narduolo, Stefania;
Open Access English
  • Country: United Kingdom
Abstract
This thesis describes our studies of the racemisation of substituted hydantoins and is divided in six chapters. Chapter 1 presents the concepts of chirality and racemisation and its implications in drug development. The literature on the stereolability of 5-substituted hydantoins is summarised. Chapter 2 describes detailed kinetic and mechanistic studies of the racemisation of (5)-5-benzylhydantoin and (5)-3-iV-methyl-5-benzylhydantoin, aimed at establishing the mechanistic aspects of racemisation of these molecules. Kinetics of H/D exchange and racemisation, kinetic isotope effects, and solvent kinetic isotope effects all favour the SeI mechanism of racemisatio...
Subjects
free text keywords: QD
Related Organizations

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