Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

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Moss, Davina J. Hensman ; Tabrizi, Sarah J ; Mead, Simon ; Kitty, Lo ; Pardiã±as, Antonio F ; Holmans, Peter ; Jones, Lesley ; Langbehn, Douglas ; Coleman, A. ; Santos, R. Dar ; Decolongon, J. ; Sturrock, A. ; Bardinet, E. ; Ret, C. Jauff ; Justo, D. ; Lehericy, S. ; Marelli, C. ; Nigaud, K. ; Valabrãgue, R. ; van den Bogaard, S. J. A. ; Dumas, E. M. ; van der Grond, J. ; T'Hart, E. P. ; Jurgens, C. ; Witjes-Ane, M. -. N. ; Arran, N. ; Callaghan, J. ; Stopford, C. ; Frost, C. ; Jones, R. ... view all 791 authors (2017)
  • Publisher: Elsevier
  • Related identifiers: doi: 10.1016/S1474-4422(17)30161-8
  • Subject: Neurology (clinical) | DNA-Binding Proteins | Huntington Disease | Disease Progression | Registries | MutS Homolog 3 Protein | Severity of Illness Index | Genome-Wide Association Study | Adult | Humans | Principal Component Analysis | R1 | Longitudinal Studies

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Theref... View more