Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

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Moss, Davina J Hensman; Tabrizi, Sarah J; Mead, Simon; Kitty, Lo; Pardiñas, Antonio F; Holmans, Peter; Jones, Lesley; Langbehn, Douglas; Coleman, A.; Santos, R Dar; Decolongon, J.; Sturrock, A.; Bardinet, E.; Ret, C Jauff; Justo, D.; Lehericy, S.; Marelli, C.; Nigaud, K.; Valabrègue, R.; van den Bogaard, S. J. A.; Dumas, E. M.; van der Grond, J.; T'Hart, E. P.; Jurgens, C.; Witjes-Ane, M. -N.; Arran, N.; Callaghan, J.; Stopford, C.; Frost, C.; Jones, R.; ... view all 794 authors
  • Publisher: Elsevier
  • Related identifiers: doi: 10.1016/S1474-4422(17)30161-8
  • Subject: Neurology (clinical) | DNA-Binding Proteins | Huntington Disease | Disease Progression | Registries | MutS Homolog 3 Protein | Severity of Illness Index | Genome-Wide Association Study | Adult | Humans | Principal Component Analysis | R1 | Longitudinal Studies

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Theref... View more