Characterising colloidal quantum dots for biomedical applications

Doctoral thesis English OPEN
Cunnah, David
  • Subject: QC

This thesis is comprised of seven sections which I will summarize here. 1. Introduces the study and sets out aims and objectives. 2. Introduces colloidal quantum dots and relevant mechanical concepts. Also serves to present the position of this work being undertaken in the field. 3. The experimental methods used throughout the thesis are introduced and described. 4. Results of preliminary studies performed on 610nm colloidal quantum dots in a PMMA matrix are presented and studied in order to develop an analytic technique to describe the dot behaviour. 5. Using the results of section 4 we show that it is possible to calculate the concentration of the dot solution using data supplied from the manufacturer and as a result we are able to calculate the photo-activation probability per dot per photon at a given photon energy. 6. Results of an extensive study of 655nm colloidal quantum dots in various pH environments in order to simulate cellular conditions. Results are analyzed at length and we propose mechanisms for the observed behaviour and the consequences of our results to the use of colloidal quantum dots in biomedical, especially cellular imaging, applications.
  • References (3)

    [1] X. Michalet, F. F. Pinaud, L. A. Bentolila, J. M. Tsay, S. Doose, J. J. Li, G. Sundaresan, A. M. Wu, S. S. Gambhir, S. Weiss Science, 307, 5709 (2005)

    [2] X. Gao, Y. Cui, R.M. Levenson, L. W. K. Chung, S. Nie, Nature Biotechnology, 22, 8 (2004)

    [3] D. R. Larson, W. R. Zipfel, R. M. W illiams, S. W. Clark, M. P. Bruches, F. M. Wise, M. W. Webb, Science, 300, 5624 (2003)

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