publication . Thesis

A molecular genetic analysis of L-asparaginase II synthesis in Erwinia Chrysanthemi NCPPB 1066

Kell, Christopher Martin;
Open Access English
  • Country: United Kingdom
Abstract
The enzyme L-asparaginase (L-asparagine amidohydrolase EC 3.5.1.1) has been shown to possess antitumour activity and has been extensively used over many years for the treatment of childhood acute lymphoblastic leukaemia. Today, this enzyme is produced commercially from either the enteric bacterium Escherichia coll or the plant pathogen Erwinla chrysanthemi NCPPB 1066.\ud \ud The following sections of this chapter have been written in the form of a review which summarises the available literature concerning L- asparaginase. The clinical, physical, biochemical, commercial and regulatory aspects of this enzyme are discussed, with particular emphasis on the chemothe...
Subjects
Medical Subject Headings: bacteria
free text keywords: QK, SB
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