Dose-response of sodium bicarbonate ingestion highlights individuality in time course of blood analyte responses

Article English OPEN
Jones, RL ; Stellingwerff, T ; Artioli, GG ; Saunders, B ; Cooper, S ; Sale, C (2016)

To defend against hydrogen cation accumulation and muscle fatigue during exercise, sodium 20 bicarbonate (NaHCO3) ingestion is commonplace. The individualised dose-response relationship 21 between NaHCO3 ingestion and blood biochemistry is unclear. The present study investigated the 22 bicarbonate, pH, base excess and sodium responses to NaHCO3 ingestion. Sixteen healthy males (23±2 23 years; 78.6±15.1 kg) attended three randomised order-balanced, non-blinded sessions, ingesting a single 24 dose of either 0.1, 0.2 or 0.3 g.kg-1BM of NaHCO3 (Intralabs, UK). Fingertip capillary blood was 25 obtained at baseline and every 10 min for 1 h, then every 15 min for a further 2 h. There was a significant 26 main effect of both time and condition for all assessed blood analytes (P≤0.001). Blood analyte 27 responses were significantly lower following 0.1 g.kg-1BM compared with 0.2 g.kg-1BM; bicarbonate 28 concentrations and base excess were highest following ingestion of 0.3 g.kg-1BM (P≤0.01). Bicarbonate 29 concentrations and pH significantly increased from baseline following all doses; the higher the dose the 30 greater the increase. Large inter-individual variability was shown in the magnitude of the increase in 31 bicarbonate concentrations following each dose (+2.0-5; +5.1-8.1; and +6.0-12.3 mmol·L-1 for 0.1, 0.2 32 and 0.3 g.kg-1BM) and in the range of time to peak concentrations (30-150; 40-165; and 75-180 min for 33 0.1, 0.2 and 0.3 g.kg-1BM). The variability in bicarbonate responses was not affected by normalisation 34 to body mass. These results challenge current practices relating to NaHCO3 supplementation and clearly 35 show the need for athletes to individualise their ingestion protocol and trial varying dosages prior to 36 competition.
  • References (29)
    29 references, page 1 of 3

    Afman, G., Garside, R.M., Dinan. N., Gant. N., Betts, J.A., & Williams, C. (2014). Effect of carbohydrate or sodium bicarbonate ingestion on performance during a validated basketball simulation test. International Journal of Sports Nutrition Exercise Metabolism, 24, 6, 632-644.

    Barbosa, L., Vera, H., Moran, S., Del Prado, M., & Lopez Alarcon, M. (2005). Reproducibility and reliability of the 13C-acetate breath test to measure gastric emptying of liquid meal in infants. Nutrition, 21, 289-294.

    Forbes, S.C., Raymer, G.H., Kowalchuk, J.M., & Marsh, G.D. (2005). NaHCO3-induced alkalosis reduces the phosphocreatine slow component during heavy intensity forearm exercise. Journal of Applied Physiology, 99, 1668-1675.

    Gannon, M.C., Nuttall, F.Q., Westphal, S.A., Neil, B.J., & Seaquist, E.R. (1989). Effects of dose of ingested glucose on plasma metabolite and hormone responses in type II diabetic subjects. Diabetes Care, 12, 544-552.

    Heigenhauser, G.J.F. (1991). Ergogenic enhancement of performance in exercise and sport: Bicarbonate loading. In: D. R. Lamb and M. H. Williams (Ed.), Prospective in Exercise Science and Sports Medicine (Vol. 4; pp. 183-212). Carmel, In: Cooper Publishing Group LLC.

    Hill, A.V. & Lupton, H. (1923). Muscular exercise, lactic acid, and the supply and utilization of oxygen.

    QJM, 16, 135-171.

    Joyce, S., Minahan, C., Anderson, M., & Osborne, M. (2011). Acute and chronic loading of sodium bicarbonate in highly trained swimmers. European Journal of Applied Physiology, 112, 1-9.

    Kahle, L., Kelly, P., Eliot, K., & Weiss, E. (2013). Acute sodium bicarbonate loading has negligible effects on resting and exercise blood pressure but causes gastrointestinal distress. Nutrition Research, 33, 479-86.

    Maughan, R.J., King, D.S., & Lea, T. (2004). Dietary supplements. Journal of Sports Sciences, 22, 95- 113.

  • Metrics
    0
    views in OpenAIRE
    0
    views in local repository
    112
    downloads in local repository

    The information is available from the following content providers:

    From Number Of Views Number Of Downloads
    Institutional Repository - IRUS-UK 0 112
Share - Bookmark