publication . Article . 2013

Tc-99m-NTP 15-5 assessment of the early therapeutic response of chondrosarcoma to zoledronic acid in the Swarm rat orthotopic model

Miot-Noirault, E.; David, E.; Vidal, A.; Peyrode, C.; Besse, S.; Dauplat, M-M.; Heymann, M-F.; Gouin, F.; Chezal, J-M.; Heymann, D.; ...
Open Access English
  • Published: 20 May 2013
  • Publisher: BioMed Central
Abstract
Background: Since proteoglycans (PGs) appear as key partners in chondrosarcoma biology, PG-targeted imaging using the radiotracer 99mTc-N-(triethylammonium)-3-propyl-[15]ane-N5 (99mTc-NTP 15-5) developed by our group was previously demonstrated to be a good single-photon emission computed tomography tracer for cartilage neoplasms. We therefore initiated this new preclinical study to evaluate the relevance of 99mTc-NTP 15-5 imaging for the in vivo monitoring and quantitative assessment of chondrosarcoma response to zoledronic acid (ZOL) in the Swarm rat orthotopic model.\ud Findings: Rats bearing chondrosarcoma in the orthotopic paratibial location were treated b...

1. World Health Organization: Cartilage tumors. In Pathology and Genetics of Tumours of Soft Tissue and Bone. Edited by Fletcher CDM, Unni KK, Mertens F. Lyon: IARC; 2002:234-257 [Kleihues P, Sobin LH (Series Editors): World Health Organization Classification of Tumors].

2. Velasco CR, Colliec-Jouault S, Redini F, Heymann D, Padrines M: Proteoglycans on bone tumor development. Drug Discov Today 2010, 13-14:553-560.

3. Miot-Noirault E, Gouin F, Vidal A, Rapp M, Maublant J, Askienazy S, Chezal JM, Heymann D, Redini F, Moins N: First preclinical imaging of primary cartilage neoplasm and its local recurrence using 99mTc-NTP 15-5 radiotracer. J Nucl Med 2009, 50:1541-1547.

4. Onishi AC, Hincker AM, Lee FY: Surmounting chemotherapy and radioresistance in chondrosarcoma: molecular mechanisms and therapeutic targets. Sarcoma 2011, 2011:381564.

5. Moriceau G, Ory B, Gobin B, Verrecchia F, Gouin F, Blanchard F, Redini F, Heymann D: Therapeutic approach of primary bone tumours by bisphosphonates. Curr Pharm Des 2010, 16:2981-2987. [OpenAIRE]

6. Gouin F, Ory B, Rédini F, Heymann D: Zoledronic acid slows down rat primary chondrosarcoma development, recurrent tumor progression after intralesional curretage and increases overall survival. Int J Cancer 2006, 119:980-984.

7. Streitbuerger A, Henrichs M, Ahrens H, Lanvers-Kaminzky C, Gouin F, Gosheger G, Hardes J: Cytotoxic effect of clodronate and zoledronate on the chondrosarcoma cell lines HTB-94 and CAL-78. Int Orthop 2011, 35:1369-1373.

8. Grimaud E, Damiens C, Rousselle AV, Passuti N, Heymann D, Gouin F: Bone remodelling and tumor grade modifications induced by interactions between bone and swarm rat chondrosarcoma. Histol Histopathol 2002, 17:1103-1111. [OpenAIRE]

9. Odri GA, Dumoucel S, Picarda G, Battaglia S, Lamoureux F, Corradini N, Rousseau J, Tirode F, Laud K, Delattre O, Gouin F, Heymann D, Redini F: Zoledronic acid as a new adjuvant therapeutic strategy for Ewing's sarcoma patients. Cancer Res 2010, 70:7610-7619. [OpenAIRE]

10. Montella L, Addeo R, Faiola V, Cennamo G, Guarrasi R, Capasso E, Mamone R, Caraglia M, Del Prete S: Zoledronic acid in metastatic chondrosarcoma and advanced sacrum chordoma: two case reports. J Exp Clin Cancer Res 2009, 28:7. [OpenAIRE]

11. Fox E, Patel S, Wathen JK, Schuetze S, Chawla S, Harmon D, Reinke D, Chugh R, Benjamin RS, Helman LJ: Phase II study of sequential gemcitabine followed by docetaxel for recurrent Ewing sarcoma, osteosarcoma, or unresectable or locally recurrent chondrosarcoma: results of sarcoma alliance for research through collaboration study 003. Oncologist 2012, 17:321.

12. Chiti A, Oyen WJG: Imaging of therapy response in oncology. Q J Nucl Med 2011, 55:587-588. [OpenAIRE]

13. Arsos G, Venizelos I, Karatzas N, Koukoulidis A, Karakatsanis C: Low-grade chondrosarcomas: a difficult target for radionuclide imaging. Case report and review of the literature. Eur J Radiol 2002, 43:66-72.

Abstract
Background: Since proteoglycans (PGs) appear as key partners in chondrosarcoma biology, PG-targeted imaging using the radiotracer 99mTc-N-(triethylammonium)-3-propyl-[15]ane-N5 (99mTc-NTP 15-5) developed by our group was previously demonstrated to be a good single-photon emission computed tomography tracer for cartilage neoplasms. We therefore initiated this new preclinical study to evaluate the relevance of 99mTc-NTP 15-5 imaging for the in vivo monitoring and quantitative assessment of chondrosarcoma response to zoledronic acid (ZOL) in the Swarm rat orthotopic model.\ud Findings: Rats bearing chondrosarcoma in the orthotopic paratibial location were treated b...

1. World Health Organization: Cartilage tumors. In Pathology and Genetics of Tumours of Soft Tissue and Bone. Edited by Fletcher CDM, Unni KK, Mertens F. Lyon: IARC; 2002:234-257 [Kleihues P, Sobin LH (Series Editors): World Health Organization Classification of Tumors].

2. Velasco CR, Colliec-Jouault S, Redini F, Heymann D, Padrines M: Proteoglycans on bone tumor development. Drug Discov Today 2010, 13-14:553-560.

3. Miot-Noirault E, Gouin F, Vidal A, Rapp M, Maublant J, Askienazy S, Chezal JM, Heymann D, Redini F, Moins N: First preclinical imaging of primary cartilage neoplasm and its local recurrence using 99mTc-NTP 15-5 radiotracer. J Nucl Med 2009, 50:1541-1547.

4. Onishi AC, Hincker AM, Lee FY: Surmounting chemotherapy and radioresistance in chondrosarcoma: molecular mechanisms and therapeutic targets. Sarcoma 2011, 2011:381564.

5. Moriceau G, Ory B, Gobin B, Verrecchia F, Gouin F, Blanchard F, Redini F, Heymann D: Therapeutic approach of primary bone tumours by bisphosphonates. Curr Pharm Des 2010, 16:2981-2987. [OpenAIRE]

6. Gouin F, Ory B, Rédini F, Heymann D: Zoledronic acid slows down rat primary chondrosarcoma development, recurrent tumor progression after intralesional curretage and increases overall survival. Int J Cancer 2006, 119:980-984.

7. Streitbuerger A, Henrichs M, Ahrens H, Lanvers-Kaminzky C, Gouin F, Gosheger G, Hardes J: Cytotoxic effect of clodronate and zoledronate on the chondrosarcoma cell lines HTB-94 and CAL-78. Int Orthop 2011, 35:1369-1373.

8. Grimaud E, Damiens C, Rousselle AV, Passuti N, Heymann D, Gouin F: Bone remodelling and tumor grade modifications induced by interactions between bone and swarm rat chondrosarcoma. Histol Histopathol 2002, 17:1103-1111. [OpenAIRE]

9. Odri GA, Dumoucel S, Picarda G, Battaglia S, Lamoureux F, Corradini N, Rousseau J, Tirode F, Laud K, Delattre O, Gouin F, Heymann D, Redini F: Zoledronic acid as a new adjuvant therapeutic strategy for Ewing's sarcoma patients. Cancer Res 2010, 70:7610-7619. [OpenAIRE]

10. Montella L, Addeo R, Faiola V, Cennamo G, Guarrasi R, Capasso E, Mamone R, Caraglia M, Del Prete S: Zoledronic acid in metastatic chondrosarcoma and advanced sacrum chordoma: two case reports. J Exp Clin Cancer Res 2009, 28:7. [OpenAIRE]

11. Fox E, Patel S, Wathen JK, Schuetze S, Chawla S, Harmon D, Reinke D, Chugh R, Benjamin RS, Helman LJ: Phase II study of sequential gemcitabine followed by docetaxel for recurrent Ewing sarcoma, osteosarcoma, or unresectable or locally recurrent chondrosarcoma: results of sarcoma alliance for research through collaboration study 003. Oncologist 2012, 17:321.

12. Chiti A, Oyen WJG: Imaging of therapy response in oncology. Q J Nucl Med 2011, 55:587-588. [OpenAIRE]

13. Arsos G, Venizelos I, Karatzas N, Koukoulidis A, Karakatsanis C: Low-grade chondrosarcomas: a difficult target for radionuclide imaging. Case report and review of the literature. Eur J Radiol 2002, 43:66-72.

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