publication . Article . Other literature type . 2009

Aortic Calcification Is Associated With Aortic Stiffness and Isolated Systolic Hypertension in Healthy Individuals

McEniery, Carmel M.; McDonnell, Barry J.; So, Alvin; Aitken, Sri; Bolton, Charlotte E.; Munnery, Margaret; Hickson, Stacey S.; Yasmin,; Maki-Petaja, Kaisa M.; Cockcroft, John; ...
Open Access
  • Published: 01 Mar 2009 Journal: Hypertension, volume 53, pages 524-531 (issn: 0194-911X, eissn: 1524-4563, Copyright policy)
  • Publisher: Ovid Technologies (Wolters Kluwer Health)
  • Country: United Kingdom
Abstract
Arterial stiffening is an independent predictor of mortality and underlies the development of isolated systolic hypertension (ISH). A number of factors regulate stiffness, but arterial calcification is also likely to be important. We tested the hypotheses that aortic calcification is associated with aortic stiffness in healthy individuals and that patients with ISH exhibit exaggerated aortic calcification compared with controls. A total of 193 healthy, medication-free subjects (mean age+/-SD: 66+/-8 years) were recruited from the community, together with 15 patients with resistant ISH. Aortic pulse wave velocity (PWV) was measured noninvasively, and aortic calci...
Subjects
Medical Subject Headings: cardiovascular system
free text keywords: Pulse wave velocity, Internal medicine, medicine.medical_specialty, medicine, business.industry, business, Heart rate, Calcification, medicine.disease, Mean arterial pressure, Cardiology, Systolic hypertension, Artery, medicine.anatomical_structure, Aortic stiffness, Aorta, medicine.artery, RC
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