publication . Article . Other literature type . 2009

Aortic Calcification Is Associated With Aortic Stiffness and Isolated Systolic Hypertension in Healthy Individuals

McEniery, Carmel M.; McDonnell, Barry J.; So, Alvin; Aitken, Sri; Bolton, Charlotte E.; Munnery, Margaret; Hickson, Stacey S.; Yasmin,; Maki-Petaja, Kaisa M.; Cockcroft, John; ...
Open Access
  • Published: 01 Mar 2009 Journal: Hypertension, volume 53, pages 524-531 (issn: 0194-911X, eissn: 1524-4563, Copyright policy)
  • Publisher: Ovid Technologies (Wolters Kluwer Health)
  • Country: United Kingdom
Arterial stiffening is an independent predictor of mortality and underlies the development of isolated systolic hypertension (ISH). A number of factors regulate stiffness, but arterial calcification is also likely to be important. We tested the hypotheses that aortic calcification is associated with aortic stiffness in healthy individuals and that patients with ISH exhibit exaggerated aortic calcification compared with controls. A total of 193 healthy, medication-free subjects (mean age+/-SD: 66+/-8 years) were recruited from the community, together with 15 patients with resistant ISH. Aortic pulse wave velocity (PWV) was measured noninvasively, and aortic calci...
Medical Subject Headings: cardiovascular system
free text keywords: Pulse wave velocity, Internal medicine, medicine.medical_specialty, medicine, business.industry, business, Heart rate, Calcification, medicine.disease, Mean arterial pressure, Cardiology, Systolic hypertension, Artery, medicine.anatomical_structure, Aortic stiffness, Aorta, medicine.artery, RC
Related Organizations
45 references, page 1 of 3

1. Franklin SS, Gustin IVW, Wong ND, Larson MG, Weber MA, Kannel WB, Levy D. Hemodynamic patterns of age-related changes in blood pressure: the Framingham Heart Study. Circulation. 1997;96: 308 -315. [OpenAIRE]

2. McEniery CM, Yasmin, Hall IR, Qasem A, Wilkinson IB, Cockcroft JR. Normal vascular ageing: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT 1). J Am Coll Cardiol. 2005;46:1753-1760.

3. Primatesta P, Poulter NR. Hypertension management and control among English adults aged 65 years and older in 2000 and 2001. J Hypertens. 2004;22:1093-1098. [OpenAIRE]

4. Laurent S, Cockcroft JR, van Bortel LM, Boutouyrie P, Giannattasio C, Hayoz D, Pannier BM, Vlachopoulos C, Wilkinson IB, Struijker-Boudier H. Abridged version of the expert consensus document on arterial stiffness. Artery Res. 2007;1:2-12.

5. Nichols WW, O'Rourke MF. McDonald's Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles. 5th ed. London, United Kingdom: Arnold; 2005.

6. Dao HH, Essalihi R, Bouvet C, Moreau P. Evolution and modulation of age-related medial elastocalcinosis: impact on large artery stiffness and isolated systolic hypertension. Cardiovasc Res. 2005;66:307-317.

7. Demer LL, Tintut Y. Mineral exploration: search for the mechanism of vascular calcification and beyond: the 2003 Jeffrey M. Hoeg Award lecture. Arterioscler Thromb Vasc Biol. 2003;23:1739 -1743. [OpenAIRE]

8. Sawabe M, Takahashi R, Matsushita S, Ozawa T, Arai T, Hamamatsu A, Nakahara K, Chida K, Yamanouchi H, Murayama S, Tanaka N. Aortic pulse wave velocity and the degree of atherosclerosis in the elderly: a pathological study based on 304 autopsy cases. Atherosclerosis. 2005; 179:345-351.

9. van Popele NM, Grobbee DE, Bots ML, Asmar R, Topouchian J, Reneman RS, Hoeks AP, van der Kuip DA, Hofman A, Witteman JC. Association between arterial stiffness and atherosclerosis: the Rotterdam Study. Stroke. 2001;32:454 - 460. [OpenAIRE]

10. Henrion D, Chillon JM, Godeau G, Muller F, Capdeville-Atkinson C, Hoffman M, Atkinson J. The consequences of aortic calcium overload following vitamin D3 plus nicotine treatment in young rats. J Hypertens. 1991;9:919 -926. [OpenAIRE]

11. Niederhoffer N, Lartaud-Idjouadiene I, Giummelly P, Duvivier C, Peslin R, Atkinson J. Calcification of medial elastic fibers and aortic elasticity. Hypertension. 1997;29:999 -1006. [OpenAIRE]

12. Yu S, Blumenthal H. The calcification of elastic fibers. I. Biochemical studies. J Gerontol. 1963;18:119 -126. [OpenAIRE]

13. Dunmore-Buyze PJ, Moreau M, Fenster A, Holdsworth DW. In vitro investigation of calcium distribution and tissue thickness in the human thoracic aorta. Physiol Meas. 2002;23:555-566. [OpenAIRE]

14. Yildiz A, Memisoglu E, Oflaz H, Yazici H, Pusuroglu H, Akkaya V, Erzengin F, Tepe S. Atherosclerosis and vascular calcification are independent predictors of left ventricular hypertrophy in chronic haemodialysis patients. Nephrol Dial Transplant. 2005;20:760 -767. [OpenAIRE]

15. Wilson PW, Kauppila LI, O'Donnell CJ, Kiel DP, Hannan M, Polak JM, Cupples LA. Abdominal aortic calcific deposits are an important predictor of vascular morbidity and mortality. Circulation. 2001;103: 1529 -1534. [OpenAIRE]

45 references, page 1 of 3
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue