publication . Article . 2014

Oral Inflammation, Tooth Loss, Risk Factors, and Association with Progression of Alzheimer’s Disease

Singhrao, Simarjit Kaur; Harding, Alice; Simmons, Tal; Robinson, Sarita Jane; Kesavalu, Lakshmyya; Crean, Stjohn;
Open Access English
  • Published: 01 Jan 2014
  • Publisher: IOS Press
  • Country: United Kingdom
Abstract
Periodontitis is a polymicrobial chronic inflammatory disease of tooth-supporting tissues with bacterial etiology affecting all age groups, becoming chronic in a subgroup of older individuals. Periodontal pathogens Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola are implicated in the development of a number of inflammatory pathologies at remote organ sites, including Alzheimer’s disease (AD). The initial inflammatory hypothesis proposed that AD hallmark proteins were the main contributors of central nervous system (CNS) inflammation. This hypothesis is expanding to include the role of infections, lifestyle, and genetic and environmental f...
Subjects
Medical Subject Headings: stomatognathic diseases
free text keywords: A400
Related Organizations
Funded by
NIH| Periodontal Pathogens and Cardiovascular Disease
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01DE020820-03
  • Funding stream: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
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