publication . Article . Other literature type . 2016

Electrospun FBG-PLA nanofibres for vascular tissue engineering

Gugutkov, D.; Gustavsson, J.; Cantini, M.; Salmeron-Sanchez, M.; Altankov, G.;
Open Access English
  • Published: 30 May 2016
  • Publisher: John Wiley and Sons Ltd
  • Country: India
Abstract
Here we report on the development of a new type of hybrid fibrinogen-polylactic acid (FBG-PLA) nanofibres (NFs) with improved stiffness, combining the good mechanical properties of PLA with the excellent cell recognition properties of native FBG. We were particularly interested in the dorsal and ventral cell response to the nanofibres' organization (random or aligned), using human umbilical endothelial cells (HUVECs) as a model system. Upon ventral contact with random NFs, the cells developed a stellate-like morphology with multiple projections. The well-developed focal adhesion complexes suggested a successful cellular interaction. However, time-lapse analysis ...
Subjects
free text keywords: Nanofiber, Biology, Cell Mobility, Polylactic acid, chemistry.chemical_compound, chemistry, Morphology (linguistics), Neovascularization, medicine.symptom, medicine, Biomedical engineering, Tissue engineering, Focal adhesion, Cell, medicine.anatomical_structure
Related Organizations
33 references, page 1 of 3

1. Arnold M, Cavalcanti-Adam A, Glass R, Blmmel J, Eck W, Kessler H and Spatz J. 2004, Activation of integrin function by nanopaterned adhesive interfaces, Chem. Phys. Chem, 3: 383-388

2. Baji A, Mai YM, Wong SC, Abtahi M, Chen P. 2010, Electrospinning polymer nanofibers: Effects on oriented morphology, structures and tensile properties, Compos. Sci. Technol., 70(5): 703-718

3. Baker S, Sigley J, Carlisle CR, Stitzel J, Berry J, Bonin K, Guthold, 2012. The Mechanical Properties of Dry, Electrospun Fibrinogen Fibers, Mater Sci Eng C Mater Biol Appl,1;32(2): 215-221

4. Baranski JD, Chaturvedi RR, Stevens KR, Eyckmans J, Carvalho B, Solorzano RD, Yang MT, Miller JS, Bhatia SN, Chen CS. 2013, Geometric control of vascular networks to enhance engineered tissue integration and function, Proc Natl Acad Sci U S A, 110(19):7586-7591

5. Chiu JB, Luu YK, Fang D, Hasiao B, Chu B, Hadjiargyurou. 2005, Electrospun nanofibrous scaffold for Biomedical Applications, J Biomed Nanotechgnol. 1: 115-123

6. Cleary MA, Geiger E, Grady C, Best C, Naito Y, Breuer C. 2012, Vascular tissue engineering: the next generation, Trend Mol Med,18 (7): 394-404

7. De Mel A, Jell G, Stevens MM, Seifalian AM. 2008, Biofunctionalization of biomaterials for accelerated in situ endothelialization: a review, [OpenAIRE]

8. Dvir T, Timko BP, Kohane S, R. Langer. 2010, Naniotechnological strategies for engineering complex tissues, Nature Nanotech, 6: 13-22

10.Fang J, Wang X, Lin T, 2011. 'Functional Applications of Electrospun Nanofibers' in Nanofibers - Production, Properties and Functional Applications, eds. Dr. Tong Lin, InTech, 285-326

11.Forner L, Salmerón-Sánchez M, Palomares M, Llena C, Amengual J. 2009, The use of atomic force microscopy in determining the stiffness and adhesion force of human dentin after exposure to bleaching agents, J Endod, 35(10): 1384-1386

12.Förstermann U, Münzel T. 2006, Endothelial nitric oxide synthase in vascular disease: from marvel to menace, Circulation, 113(13): 1708- 1714 [OpenAIRE]

13.Fu X, Wang H. 2012, Spatial arrangement of polycaprolactone/collagen nanofiber scaffolds regulates the wound healing related behaviors of human adipose stromal cells, Tissue Eng, Part A, 18: 631-642

14.Geiger B, Spatz JP, Bershadsky AD. 2009, Environmental sensing through focal adhesions, Nat Rev Mol Cell Biol, 10(1): 21-33

15.Grinnell F. 2003, Fibroblast biology in three-dimensional collagen [OpenAIRE]

16.Guelcher SA, Goldstein AS. 2009, Effect of fiber diameter and alignment of electrospun polyurethane meshes on meshenchimal progenitor cells, Tissue Eng Partr A, 15: 2435-2445

33 references, page 1 of 3
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