publication . Article . Other literature type . 2016

Electrospun FBG-PLA nanofibres for vascular tissue engineering

Gugutkov, D.; Gustavsson, J.; Cantini, M.; Salmeron-Sanchez, M.; Altankov, G.;
Open Access English
  • Published: 30 May 2016
  • Publisher: John Wiley and Sons Ltd
  • Country: India
Here we report on the development of a new type of hybrid fibrinogen-polylactic acid (FBG-PLA) nanofibres (NFs) with improved stiffness, combining the good mechanical properties of PLA with the excellent cell recognition properties of native FBG. We were particularly interested in the dorsal and ventral cell response to the nanofibres' organization (random or aligned), using human umbilical endothelial cells (HUVECs) as a model system. Upon ventral contact with random NFs, the cells developed a stellate-like morphology with multiple projections. The well-developed focal adhesion complexes suggested a successful cellular interaction. However, time-lapse analysis ...
free text keywords: Nanofiber, Biology, Cell Mobility, Polylactic acid, chemistry.chemical_compound, chemistry, Morphology (linguistics), Neovascularization, medicine.symptom, medicine, Biomedical engineering, Tissue engineering, Focal adhesion, Cell, medicine.anatomical_structure
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