publication . Thesis

Complex phenotypic analysis to identify genes which contribute to or modify the development of Alzheimer's disease.

Hollingworth, Paul.;
Open Access English
  • Country: United Kingdom
Abstract
Late-onset Alzheimer's disease (LOAD) is a heritable disorder. It is invariably characterised by a decline in cognitive abilities, however, marked variation in behavioural symptoms and age at onset are observed between sufferers. This clinical heterogeneity may be genetically modified, hence, may provide a productive avenue of exploration for those seeking to unravel the genetic aetiology of LOAD. This thesis employed a sequential three stage approach to search for loci implicated in the development of genetically influenced features of the disease. Behavioural symptoms in 1,120 unrelated individuals with LOAD were assessed using the Neuropsychiatric Inventory. ...
Subjects
free text keywords: RC0321
Related Organizations
Funded by
WT
Project
  • Funder: Wellcome Trust (WT)
204 references, page 1 of 14

5. General discussion....................................................................... 180 5.1 Summary of findings.................................................................................180 5.2 Implications and future research............................................................ 183 5.3 Conclusions............................................................................................... 191

4.1 Basic characteristicsof the family based samples used for linkage analysis.................................................. 151

4.2 Pairwise symptom classifications among relative pairs in the UK, NIMH and combined sample..........................................................................152

4.3 Summary of linkage results after including pairwise age at onset mean, difference and APOE.......................................................................... 153

4.4 Variation in IBD and maximum LOD score with mean age at onset for chromosomes with significant mean age at onset effects..............................158

4.5 Summary of linkage results after including psychosis and APOE...................159

4.6 Summary of linkage results after including aggression and APOE.................164

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