publication . Article . Other literature type . 2016

Continuous Effector CD8+ T Cell Production in a Controlled Persistent Infection Is Sustained by a Proliferative Intermediate Population

Chu, H. Hamlet; Chan, Shiao-Wei; Gosling, John Paul; Blanchard, Nicolas; Tsitsiklis, Alexandra; Lythe, Grant; Shastri, Nilabh; Molina-París, Carmen; Robey, Ellen A.;
Open Access English
  • Published: 01 Jul 2016
  • Publisher: Elsevier
  • Country: United Kingdom
Abstract
Highly functional CD8+ effector T (Teff) cells can persist in large numbers during controlled persistent infections, as exemplified by rare HIV-infected individuals who control the virus. Here we examined the cellular mechanisms that maintain ongoing T effector responses using a mouse model for persistent Toxoplasma gondii infection. In mice expressing the protective MHC-I molecule, H-2Ld, a dominant T effector response against a single parasite antigen was maintained without a contraction phase, correlating with ongoing presentation of the dominant antigen. Large numbers of short-lived Teff cells were continuously produced via a proliferative, antigen-dependent...
Subjects
free text keywords: Biology, Virology, Toxoplasma gondii, biology.organism_classification, Effector, Virus, Immunology, CD8, Population, education.field_of_study, education, Cytotoxic T cell, Antigen, Major histocompatibility complex, biology.protein

43.Nelson, R.W., McLachlan, J.B., Kurtz, J.R., and Jenkins, M.K. (2013). CD4+ T cell persistence and function after infection are maintained by lowlevel peptide:MHC class II presentation. J Immunol 190, 2828-2834.

44.Olson, J.A., McDonald-Hyman, C., Jameson, S.C., and Hamilton, S.E. (2013). Effector-like CD8(+) T cells in the memory population mediate potent protective immunity. Immunity 38, 1250-1260.

45.Paley, M.A., Kroy, D.C., Odorizzi, P.M., Johnnidis, J.B., Dolfi, D.V., Barnett, B.E., Bikoff, E.K., Robertson, E.J., Lauer, G.M., Reiner, S.L., and Wherry, E.J. (2012). Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection. Science 338, 1220-1225. [OpenAIRE]

46.Rohr, J.C., Gerlach, C., Kok, L., and Schumacher, T.N. (2014). Single cell behavior in T cell differentiation. Trends Immunol 35, 170-177.

47.Sallusto, F., Lenig, D., Forster, R., Lipp, M., and Lanzavecchia, A. (1999). Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708-712. [OpenAIRE]

48.Shah, S., Grotenbreg, G.M., Rivera, A., and Yap, G.S. (2015). An extrafollicular pathway for the generation of effector CD8(+) T cells driven by the proinflammatory cytokine, IL-12. Elife 4.

49.Simonetta, F., Hua, S., Lecuroux, C., Gerard, S., Boufassa, F., SaezCirion, A., Pancino, G., Goujard, C., Lambotte, O., Venet, A., and Bourgeois, C. (2014). High eomesodermin expression among CD57+ CD8+ T cells identifies a CD8+ T cell subset associated with viral control during chronic human immunodeficiency virus infection. J Virol 88, 11861- 11871. [OpenAIRE]

50.Snyder, C.M., Cho, K.S., Bonnett, E.L., Allan, J.E., and Hill, A.B. (2011). Sustained CD8+ T cell memory inflation after infection with a single-cycle cytomegalovirus. PLoS Pathog 7, e1002295.

51.Snyder, C.M., Cho, K.S., Bonnett, E.L., van Dommelen, S., Shellam, G.R., and Hill, A.B. (2008). Memory inflation during chronic viral infection is maintained by continuous production of short-lived, functional T cells. Immunity 29, 650-659.

52.Torti, N., Walton, S.M., Brocker, T., Rulicke, T., and Oxenius, A. (2011). Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection. PLoS Pathog 7, e1002313. [OpenAIRE]

53.Turner, D.L., Cauley, L.S., Khanna, K.M., and Lefrancois, L. (2007). Persistent antigen presentation after acute vesicular stomatitis virus infection. J Virol 81, 2039-2046.

54.Vezys, V., Masopust, D., Kemball, C.C., Barber, D.L., O'Mara, L.A., Larsen, C.P., Pearson, T.C., Ahmed, R., and Lukacher, A.E. (2006). Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection. J Exp Med 203, 2263- 2269. [OpenAIRE]

55.Vidal, S.M., and Lanier, L.L. (2006). NK cell recognition of mouse cytomegalovirus-infected cells. Curr Top Microbiol Immunol 298, 183-206.

56.Virgin, H.W., Wherry, E.J., and Ahmed, R. (2009). Redefining chronic viral infection. Cell 138, 30-50.

Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue