publication . Article . Other literature type . 2016

Continuous Effector CD8+ T Cell Production in a Controlled Persistent Infection Is Sustained by a Proliferative Intermediate Population

Chu, H. Hamlet; Chan, Shiao-Wei; Gosling, John Paul; Blanchard, Nicolas; Tsitsiklis, Alexandra; Lythe, Grant; Shastri, Nilabh; Molina-París, Carmen; Robey, Ellen A.;
Open Access English
  • Published: 01 Jul 2016
  • Publisher: Elsevier
  • Country: United Kingdom
Highly functional CD8+ effector T (Teff) cells can persist in large numbers during controlled persistent infections, as exemplified by rare HIV-infected individuals who control the virus. Here we examined the cellular mechanisms that maintain ongoing T effector responses using a mouse model for persistent Toxoplasma gondii infection. In mice expressing the protective MHC-I molecule, H-2Ld, a dominant T effector response against a single parasite antigen was maintained without a contraction phase, correlating with ongoing presentation of the dominant antigen. Large numbers of short-lived Teff cells were continuously produced via a proliferative, antigen-dependent...
free text keywords: Biology, Virology, Toxoplasma gondii, biology.organism_classification, Effector, Virus, Immunology, CD8, Population, education.field_of_study, education, Cytotoxic T cell, Antigen, Major histocompatibility complex, biology.protein

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