Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy

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Iori, Valentina; Iyer, Anand M.; Ravizza, Teresa; Beltrame, Luca; Paracchini, Lara; Marchini, Sergio; Cerovic, Milica; Hill, Cameron; Ferrari, Mariella; Zucchetti, Massimo; Molteni, Monica; Rossetti, Carlo; Brambilla, Riccardo; Steve White, H.; D'Incalci, Maurizio; Aronica, Eleonora; Vezzani, Annamaria;
(2017)

We recently discovered that forebrain activation of the IL-1 receptor/Toll-like receptor (IL-1R1/TLR4) innate immunity signal plays a pivotal role in neuronal hyperexcitability underlying seizures in rodents. Since this pathway is activated in neurons and glia in human ... View more
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