publication . Thesis . Other literature type . 2017

Characterisation of Drug-Specific T-Cell Responses in Hypersensitive Patients and Healthy Donors

Al-Attar, ZI;
Open Access English
  • Published: 01 Jan 2017
  • Country: United Kingdom
Abstract
Drug hypersensitivity reactions represent a significant clinical problem and an impediment to drug development. It is currently impossible develop drugs with no immunological liability; furthermore, it is very difficult to predict which individuals will develop hypersensitivity when exposed to a therapeutic treatment regimen. This is because susceptibility is a function of the chemistry of the drug, the genetic background of the patient and environmental factors such as patient demographics, disease and concomitant medications. In this study, we focused on two drugs: piperacillin and telaprevir as examples of idiosyncratic hypersensitivity reactions. Regarding p...
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