Thrombin generation: a comparison of assays using platelet-poor and -rich plasma and whole blood samples from healthy controls and patients with a history of venous thromboembolism

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Tappenden, Kerry A.; Gallimore, Michael J.; Evans, Gillian; Mackie, Ian J.; Jones, David Wynne;

We have developed a whole blood thrombin generation (TG) assay whereby TG is initiated with a low-tissue factor concentration and monitored using a fluorogenic thrombin substrate. Significantly higher values were found in blood samples from 50 patients with a history of... View more
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