Drug release from E chemistry hypromellose tablets using the Bio-Dis USP type III apparatus: An evaluation of the effect of systematic agitation and ionic strength

Article English OPEN
Asare-Addo, Kofi ; Šupuk, Enes ; Mahdi, Mohammed H. ; Adebisi, Adeola O. ; Nep, Elijah ; Conway, Barbara R. ; Kaialy, Waseem ; Al-Hamidi, Hiba ; Nokhodchi, Ali (2016)

The aim of the study was to evaluate the effect of systematic agitation, increasing ionic strength and gel strength on drug release from a gel-forming matrix (HPMC E10M, E4M and E50LV) using USP type III Bio-Dis apparatus with theophylline as a model drug. The triboelectric charging; particle sizing, water content, true density and SEM of all the hypromellose grades, theophylline and formulated blends were characterised. The results showed that balanced inter-particulate forces exist between drug particles and the excipient surface and this enabled optimum charge to mass ratio to be measured. Agitation and ionic strength affected drug release from E50LV and E4M tablet matrices in comparison to the E10M tablet matrices. Drug release increased substantially when water was used as the dissolution media relative to media at pH 1.2 (containing 0.4 M NaCl). The results showed all f2 values for the E10M tablet matrices were above 50 suggesting the drug release from these tablet matrices to be similar. Rheological data also explained the different drug release behaviour with the stress required to yield/erode being 1 Pa, 150 Pa, and 320 Pa, for the E50LV, E4M and E10M respectively. The stiffness of the gel was also found to be varied from 2.5 Pa, 176.2 Pa and 408.3 Pa for the E50LV, E4M and E10M respectively. The lower G’ value can be explained by a softer gel being formed after tablet introduction into the dissolution media thereby indicating faster drug release.
  • References (51)
    51 references, page 1 of 6

    [1] F. Lotfipour, A. Nokhodchi, M. Saeedi, S. Norouzi-Sani, J. Sharbafi, M.R. SiahiShadbad, The effect of hydrophilic and lipophilic polymers and fillers on the release rate of atenolol from HPMC matrices, Farmaco, 59 (2004) 819

    [2] S. Takka, S. Rajbhandari, A. Sakr, Effect of anionic polymers on the release of propranolol hydrochloride from matrix tablets, Eur. J. Pharm. Biopharm., 52 (2001) 75

    [3] C.G. Cameron, J.W. McGinit, Controlled-Release Theophylline Tablet Formulations Containing Acrylic Resins, II. Combination Resin Formulations, Drug Dev. Ind. Pharm., 13 (1987) 1409

    [4] G.S. Rekhi, R.V. Nellore, A.S. Hussain, L.G. Tillman, H.J. Malinowski, L.L. Augsburger, Identification of critical formulation and processing variables for metoprolol tartrate extended-release (ER) matrix tablets, J. Control. Release, 59 (1999) 327.

    [5] M.A. Vandelli, E. Leo, F. Foni, M.T. Bernabei, Drug release from perforated matrices containing hydroxypropylcellulose, Int. J. Pharm., 171 (1998) 165.

    [6] B. Saša, P. Odon, S. Stane, K. Julijana, Analysis of surface properties of cellulose ethers and drug release from their matrix tablets, Eur. J. Pharm. Sci., 27 (2006) 375.

    [7] M.R. Siahi-Shadbad, K. Asare-Addo, K. Azizian, D. Hassanzadeh, A. Nokhodchi, Release behaviour of propranolol HCl from hydrophilic matrix tablets containing psyllium powder in combination with hydrophilic polymers, AAPS PharmSciTech, 12 (2011) 1176

    [8] K. Asare-Addo, A.O. Adebisi, A. Nokhodchi, Agitation Sequence and Ionic Strength on In-Vitro Drug Release from Hypromellose-The Influence of Compaction Force, Int Journal of Basic Medical Sciences and Pharmacy (IJBMSP), 5 (2015) 1

    [9] B. Abrahamsson, K. Roos, J. Sjogren, Investigation of prandial effects on hydrophilic matrix tablets, Drug Dev. Ind. Pharm., 25 (1999) 765

    [10] W. Phuapradit, S. Bolton, The influence of tablet density on the human oral absorption of sustained release acetaminophen matrix tablets, Drug Dev. Ind. Pharm., 17 (1991) 1097

  • Metrics
    0
    views in OpenAIRE
    0
    views in local repository
    72
    downloads in local repository

    The information is available from the following content providers:

    From Number Of Views Number Of Downloads
    University of Huddersfield Repository - IRUS-UK 0 72
Share - Bookmark