PNAS plus: plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state

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Babbitt, S.E.; Altenhofen, L.; Cobbold, S.A.; Istvan, E.S.; Fennell, C.; Doerig, C.; Llinas, M.; Goldberg, D.E.;
(2012)
  • Publisher: National Academy of Sciences
  • Subject:
    mesheuropmc: parasitic diseases

The human malaria parasite Plasmodium falciparum is auxotrophic for most amino acids. Its amino acid needs are met largely through the degradation of host erythrocyte hemoglobin; however the parasite must acquire isoleucine exogenously, because this amino acid is not pr... View more
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