Cytogenetic and immunohistochemical characterization of Mammary Analogue Secretory Carcinoma of salivary glands

Article English OPEN
Khurram, S.A.; Sultan-Khan, J.; Atkey, N.; Speight, P.M.;
(2016)
  • Publisher: Elsevier

Objectives: Mammary analogue secretory carcinoma (MASC), initially considered a sub-set of acinic cell carcinoma (ACC) harbours an ETV6 translocation [t(12:15)(p13:25q)] and is now regarded as a distinct entity. Several putative markers to differentiate MASC from ACC ha... View more
  • References (9)

    1. Skálová A, Vanecek T, Sima R, et al. Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol. 2010;34(5):599-608.

    2. Sethi R, Kozin E, Remenschneider A, et al. Mammary analogue secretory carcinoma: update on a new diagnosis of salivary gland malignancy. Laryngoscope. 2014;124(1):188-95.

    3. Hirokawa M, Sugihara K, Sai T, et al. Secretory carcinoma of the breast: a tumour analogoTusto salivary gland acinic cell carcinoma? Histopathology. 2002;40(3):223-9.

    14. Caputo A, Caci E, Ferrera L, et al. TMEM16A, a membrane protein associated with calciumdependent chloride channel activity. Science 2008;322:590-594.

    15. Schroeder BC, Cheng T, Jan YN, et al. Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell 2008;134:1019-1029.

    16. Yang YD, Cho H, Koo JY, et al. TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature 2008;455:1210-1215.

    17. Griffith CC, Stelow EB, Saqi A, et al. The cytological features of mammary analogue secretory carcinoma: a series of 6 molecularly confirmed cases. Cancer Cytopathol. 2013;121(5):234-41.

    18. Tognon C, Knezevich SR, Huntsman D, et al. Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell. 2002;2(5):367-76.

    19. Bokemeyer A, Eckert C, Meyr F, et al. Copy number genome alterations are associated wTith treatment response and outcome in relapsed childhood ETV6/RUNX1-positive acute lymphoblastic leukemia. Haematologica. 2014; 99:706-714. 31. Jung MJ, Song JS, Kim SY, et al. Finding and characterizing mammary analogue secretory carcinoma of the salivary gland. Korean J Pathol. 2013;47(1):36-43.

  • Metrics
Share - Bookmark