Understanding the Wolbachia-mediated inhibition of arboviruses in mosquitoes: progress and challenges

Article English OPEN
Rainey, Stephanie M. ; Shah, Pranav ; Kohl, Alain ; Dietrich, Isabelle (2014)
  • Publisher: Society for General Microbiology
  • Related identifiers: doi: 10.1099/vir.0.057422-0
  • Subject:
    mesheuropmc: biochemical phenomena, metabolism, and nutrition | viruses | parasitic diseases

Arthropod-borne viruses (arboviruses) pose a considerable threat to human and animal health, yet effective control measures have proven difficult to implement, and novel means of controlling their replication in arthropod vectors, such as mosquitoes, are urgently required. One of the most exciting approaches to emerge from research on arthropods is the use of the endosymbiotic intracellular bacterium Wolbachia to control arbovirus transmission from mosquito to vertebrate. These α-proteobacteria propagate through insects, in part through modulation of host reproduction, thus ensuring spread through species and maintenance in nature. Since it was discovered that Wolbachia endosymbiosis inhibits insect virus replication in Drosophila species, these bacteria have also been shown to inhibit arbovirus replication and spread in mosquitoes. Importantly, it is not clear how these antiviral effects are mediated. This review will summarize recent work and discuss determinants of antiviral effectiveness that may differ between individual Wolbachia/vector/arbovirus interactions. We will also discuss the application of this approach to field settings and the associated risks.
  • References (174)
    174 references, page 1 of 18

    Acosta, E. G., Castilla, V. & Damonte, E. B. (2008). Functional entry of dengue virus into Aedes albopictus mosquito cells is dependent on clathrin-mediated endocytosis. J Gen Virol 89, 474-484.

    Acosta, E. G., Castilla, V. & Damonte, E. B. (2009). Alternative infectious entry pathways for dengue virus serotypes into mammalian cells. Cell Microbiol 11, 1533-1549.

    Alphey, L., McKemey, A., Nimmo, D., Neira Oviedo, M., Lacroix, R., Matzen, K. & Beech, C. (2013). Genetic control of Aedes mosquitoes.

    Pathog Glob Health 107, 170-179.

    Armbruster, P., Damsky, W. E., Jr, Giordano, R., Birungi, J., Munstermann, L. E. & Conn, J. E. (2003). Infection of New- and Old-World Aedes albopictus (Diptera: Culicidae) by the intracellular parasite Wolbachia: implications for host mitochondrial DNA evolution. J Med Entomol 40, 356-360.

    Asgari, S. (2013). MicroRNA functions in insects. Insect Biochem Mol Biol 43, 388-397.

    Avadhanula, V., Weasner, B. P., Hardy, G. G., Kumar, J. P. & Hardy, R. W. (2009). A novel system for the launch of alphavirus RNA synthesis reveals a role for the Imd pathway in arthropod antiviral response. PLoS Pathog 5, e1000582.

    Bartholomay, L. C., Waterhouse, R. M., Mayhew, G. F., Campbell, C. L., Michel, K., Zou, Z., Ramirez, J. L., Das, S., Alvarez, K. & other authors (2010). Pathogenomics of Culex quinquefasciatus and metaanalysis of infection responses to diverse pathogens. Science 330, 88-90.

    (2002). High Wolbachia density in insecticide-resistant mosquitoes.

    Proc Biol Sci 269, 1413-1416.

  • Metrics
    No metrics available
Share - Bookmark