aPKC inhibition by Par3 CR3 flanking regions controls substrate access and underpins apical-junctional polarization

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McDonald, Neil Q.;
  • Publisher: Elsevier
  • Subject: bcs
    mesheuropmc: animal structures | hemic and immune systems | musculoskeletal diseases

Atypical protein kinase C (aPKC) is a key apical-basal\ud polarity determinant and Par complex component.\ud It is recruited by Par3/Baz (Bazooka in Drosophila)\ud into epithelial apical domains through high-affinity\ud interaction. Paradoxically, aPKC also phosphorylat... View more
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