The molecular relationship between antigenic domains and epitopes on hCG

Article English OPEN
Berger, Peter; Lapthorn, Adrian J.;
(2016)
  • Publisher: Elsevier

Antigenic domains are defined to contain a limited number of neighboring epitopes recognized by antibodies (Abs) but their molecular relationship remains rather elusive. We thoroughly analyzed the antigenic surface of the important pregnancy and tumor marker human chori... View more
  • References (21)
    21 references, page 1 of 3

    [1] J.F. O'Connor, S. Birken, J.W. Lustbader, A. Krichevsky, Y. Chen, R.E. Canfield, Recent advances in the chemistry and immunochemistry of human chorionic gonadotropin: impact on clinical measurements, Endocr Rev, 15 (1994) 650-683.

    [2] U.H. Stenman, H. Alfthan, K. Hotakainen, Human chorionic gonadotropin in cancer, Clin Biochem, 37 (2004) 549-561.

    [3] U.H. Stenman, A. Tiitinen, H. Alfthan, L. Valmu, The classification, functions and clinical use of different isoforms of HCG, Hum Reprod Update, 12 (2006) 769-784.

    [4] P. Berger, C. Sturgeon, Pregnancy testing with hCG--future prospects, Trends in endocrinology and metabolism: TEM, 25 (2014) 637-648.

    [5] S.F. de Medeiros, R.J. Norman, Human choriogonadotrophin protein core and sugar branches heterogeneity: basic and clinical insights, Hum Reprod Update, 15 (2009) 69-95.

    [6] U.H. Stenman, J.M. Bidart, S. Birken, K. Mann, B. Nisula, J. O'Connor, Standardization of protein immunoprocedures. Choriogonadotropin (CG), Scand J Clin Lab Invest Suppl, 216 (1993) 42-78.

    [7] P. Berger, C. Sturgeon, J.M. Bidart, E. Paus, R. Gerth, M. Niang, A. Bristow, S. Birken, U.H. Stenman, The ISOBM TD-7 Workshop on hCG and related molecules. Towards user-oriented standardization of pregnancy and tumor diagnosis: assignment of epitopes to the three-dimensional structure of diagnostically and commercially relevant monoclonal antibodies directed against human chorionic gonadotropin and derivatives, Tumor Biol, 23 (2002) 1-38.

    [8] S. Birken, P. Berger, J.M. Bidart, M. Weber, A. Bristow, R. Norman, C. Sturgeon, U.H. Stenman, Preparation and characterization of new WHO reference reagents for human chorionic gonadotropin and metabolites, Clin Chem, 49 (2003) 144-154.

    [9] A. Bristow, P. Berger, J.M. Bidart, S. Birken, R. Norman, U.H. Stenman, C. Sturgeon, Establishment, value assignment, and characterization of new WHO reference reagents for six molecular forms of human chorionic gonadotropin, Clin Chem, 51 (2005) 177-182.

    [10] C.M. Sturgeon, P. Berger, J.M. Bidart, S. Birken, C. Burns, R.J. Norman, U.H. Stenman, Differences in recognition of the 1st WHO international reference reagents for hCG-related isoforms by diagnostic immunoassays for human chorionic gonadotropin, Clin Chem, 55 (2009) 1484-1491.

  • Bioentities (3)
    1hrp Protein Data Bank
    1qfw Protein Data Bank
    1sbs Protein Data Bank
  • Metrics
Share - Bookmark