Synthesis and biological evaluation of pyrimidine nucleoside monophosphate prodrugs targeted against influenza virus

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Meneghesso, Silvia; Vanderlinden, Evelien; Stevaert, Annelies; McGuigan, Christopher; Balzarini, Jan; Naesens, Lieve;

Uridine-based nucleoside analogues have often been found to have relatively poor antiviral activity. Enzymatic assays, evaluating inhibition of influenza virus RNA polymerase, revealed that some uridine triphosphate derivatives displayed inhibitory activity on UTP incor... View more
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