Pulsed ultrasound modulated optical tomography utilizing the harmonic response of lock-in detection

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Ruan, H. ; Mather, M.L. ; Morgan, Stephen P. (2013)

Ultrasound modulated optical tomography (USMOT) can image the optical properties of a scattering\ud medium at a spatial resolution approaching that of ultrasound (US). A lock-in parallel speckle detection\ud technique is proposed to detect pulsed US modulated light using a multipixel detector. The frequency\ud components of the pass band match those of the US pulse train and provide efficient detection. The modulation\ud depth is extracted by taking the difference between a pair of speckle patterns modulated by a pair\ud of phase-inversed US bursts. Modification to pulse inversion mode enables the second harmonic US\ud modulation due to nonlinear US propagation to be detected. © 2013 Optical Society of America\ud OCIS codes: (110.6150) Speckle imaging; (110.0113) Imaging through turbid media.
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