Preliminary evidence that glucose ingestion facilitates prospective memory performance

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Riby, LM ; Law, AS ; Mclaughlin, J ; Murray, J

Previous research has found that the ingestion of glucose boosts task performance in the memory domain (including tasks tapping episodic, semantic and working memory). The present pilot study tested the hypothesis that glucose ingestion would enhance performance on a test of prospective memory. In a between subjects design, 56 adults ranging from 17-80 years of age performed a computerized prospective memory task and an attention (filler) task after 25g of glucose or a sweetness matched placebo. Blood glucose measurements were also taken to assess the impact of individual differences on glucose regulation. After the drink containing glucose, cognitive facilitation was observed on the prospective memory task after excluding subjects with impaired fasting glucose level. Specifically, subjects receiving glucose were 19% more accurate than subjects receiving a placebo, a trend that was marginally non-significant, F(1,41)=3.4, p=0.07 but that had a medium effect size, d=0.58. Subjects receiving glucose were also significantly faster on the prospective memory task, F(1,35) = 4.8, p<0.05, d = 0.6. In addition, elevated baseline blood glucose (indicative of poor glucose regulation) was associated with slower prospective memory responding, F(1, 35) = 4.4, p<0.05, d = 0.57. These data add to the growing body of evidence suggesting that both memory and executive functioning can benefit from the increased provision of glucose to the brain. \ud \ud \ud KEYWORDS: Carbohydrates, Glucose, Glucose Regulation, Cognition, Mental Performance, Prospective Memory
  • References (37)
    37 references, page 1 of 4

    1. Foster JK, Lidder PG, Sünram S. Glucose and memory: fractionation of enhancement effects? Psychopharmacology 1998; 137: 259-270.

    2. Kennedy DO, Scholey AB. Glucose administration, heart rate and cognitive performance: effects of increasing mental effort. Psychopharmacology 2000; 149: 63- 71.

    3. Meikle A, Riby LM, Stollery B. The impact of glucose ingestion and gluco-regulatory control on cognitive performance: a comparison of younger and middle aged adults. Hum Psychopharmacol 2004; 19: 523-35.

    4. Riby LM, McLaughlin J, Riby DM, Graham C. Lifestyle, glucose regulation and the cognitive effects of glucose load in middle-aged adults. Br J Nutr 2008; 100: 1128- 1134.

    5. Manning CA, Parsons MW, Gold PE. Anterograde and retrograde enhancement of 24- h memory by glucose in elderly humans. Behav Neural Biol 1992; 5: 125-30.

    6. Riby LM, Meikle A, Glover C. The effects of age, glucose ingestion and glucoregulatory control on episodic memory. Age Ageing 2004; 33: 483-487.

    7. Riby LM, Marriott A, Bullock R, Hancock J, Smallwood J, McLaughlin J. The Effects of glucose ingestion and glucose regulation on memory performance in older adults with Mild Cognitive Impairment. Eur J Clin Nutr 2009; 63: 566-571.

    8. Manning CA, Ragozzino ME, Gold PE. Glucose enhancement of memory in patients with probable senile dementia of the Alzheimer's type. Neurobiol Aging 1993; 14: 523-528.

    9. Gradman TJ, Laws A, Thompson LW, Reaven GM. Verbal learning and/or memory improves with glycemic control in older subjects with non-insulin-dependent diabetes mellitus. J Am Geriatr Soc. 1993; 41: 1305-12.

    10. McNay EC, Fries TM, Gold PE. Decreases in rat extracellular hippocampal glucose concentration associated with cognitive demand during a spatial task. Proc Nat Acad Sci USA 2000; 97; 2881-2885.

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