Treatment of established osteoporosis: a systematic review and cost-utility analysis

Article English OPEN
Kanis, JA ; Brazier, JE ; Stevenson, M ; Calvert, NW ; Lloyd Jones, M (2002)
  • Publisher: NIHR Health Technology Assessment Programme
  • References (27)
    27 references, page 1 of 3

    1 Introduction .................................................. Established osteoporosis................................ Significance of osteoporosis.......................... Intervention strategies ..................................

    2 Therapeutic intervention in osteoporosis .................................................. 7 Methodology .................................................. 7 Evidence from clinical trials.......................... 10

    3 Synthesis of data and discussion .............. 39 The quality of evidence ................................ 39 The efficacy of intervention.......................... 39 Discussion ...................................................... 45

    4 Epidemiology, costs and utilities .............. 49 Osteoporotic fracture .................................... 49 BMD and fracture risk .................................. 52 Fracture risk in established osteoporosis .... 54 Consequences of fracture.............................. 56 Breast cancer and cardiovascular disease .... 58 Health state utility values .............................. 59 A review of costing ........................................ 67

    5 Health economics model .......................... 77 Model approach ............................................ 77 Overview of model ........................................ 78 Population of the model .............................. 80 Default state transition probabilities ............ 81 Adjustments to the default transition probabilities.................................................... 82 Treatment ...................................................... 83

    7 Discussion and conclusions ........................ 105 Treatment effects .......................................... 105 Health state utility values in established osteoporosis.................................................... 107 Hazard functions in established osteoporosis.................................................... 107 Constraints of the model .............................. 107 Implications for practice .............................. 108 Recommendations for further research ...... 108 9 3 : p u

    6 o

    3 r

    q a s 3

    ab ra lau te m n 1 15 00 00 (eq

  • Metrics
    0
    views in OpenAIRE
    0
    views in local repository
    188
    downloads in local repository

    The information is available from the following content providers:

    From Number Of Views Number Of Downloads
    LSHTM Research Online - IRUS-UK 0 188
Share - Bookmark