Resting state connectivity and cognitive performance in adults with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Other literature type, Article English OPEN
Cullen, Breda ; Moreton, Fiona C ; Stringer, Michael S ; Krishnadas, Rajeev ; Kalladka, Dheeraj ; López-González, Maria R ; Santosh, Celestine ; Schwarzbauer, Christian ; Muir, Keith W (2016)

Cognitive impairment is an inevitable feature of cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), affecting executive function, attention and processing speed from an early stage. Impairment is associated with structural markers such as lacunes, but associations with functional connectivity have not yet been reported. Twenty-two adults with genetically-confirmed CADASIL (11 male; aged 49.8 ± 11.2 years) underwent functional magnetic resonance imaging at rest. Intrinsic attentional/executive networks were identified using group independent components analysis. A linear regression model tested voxel-wise associations between cognitive measures and component spatial maps, and Pearson correlations were performed with mean intra-component connectivity z-scores. Two frontoparietal components were associated with cognitive performance. Voxel-wise analyses showed an association between one component cluster and processing speed (left middle temporal gyrus; peak −48, −18, −14; ZE = 5.65, pFWEcorr = 0.001). Mean connectivity in both components correlated with processing speed (r = 0.45, p = 0.043; r = 0.56, p = 0.008). Mean connectivity in one component correlated with faster Trailmaking B minus A time (r = −0.77, p < 0.001) and better executive performance (r = 0.56, p = 0.011). This preliminary study provides evidence for associations between cognitive performance and attentional network connectivity in CADASIL. Functional connectivity may be a useful biomarker of cognitive performance in this population.
  • References (38)
    38 references, page 1 of 4

    1. Chabriat H, Joutel A, Dichgans M, Tournier-Lasserve E, Bousser MG. CADASIL. Lancet Neurology 2009; 8(7): 643-653.

    2. Buffon F, Porcher R, Hernandez K, Kurtz A, Pointeau S, Vahedi K et al. Cognitive profile in CADASIL. Journal of Neurology Neurosurgery and Psychiatry 2006; 77(2): 175- 180.

    3. Dichgans M. Cognition in CADASIL. Stroke 2009; 40(3): S45-S47.

    4. Peters N, Opherk C, Danek A, Ballard C, Herzog J, Dichgans M. The pattern of cognitive performance in CADASIL: A monogenic condition leading to subcortical ischemic vascular dementia. Am J Psychiat 2005; 162(11): 2078-2085.

    5. Duering M, Gonik M, Malik R, Zieren N, Reyes S, Jouvent E et al. Identification of a strategic brain network underlying processing speed deficits in vascular cognitive impairment. Neuroimage 2013; 66: 177-183.

    6. Lee JS, Choi JC, Kang SY, Kang JH, Na HR, Park JK. Effects of Lacunar Infarctions on Cognitive Impairment in Patients with Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. J Clin Neurol 2011; 7(4): 210-214.

    7. Liem MK, Oberstein SAJL, Haan J, Van der Neut IL, Ferrari MD, Van Buchem MA et al. MRI correlates of cognitive decline in CADASIL A 7-year follow-up study. Neurology 2009; 72(2): 143-148.

    8. Zieren N, Duering M, Peters N, Reyes S, Jouvent E, Herve D et al. Education modifies the relation of vascular pathology to cognitive function: cognitive reserve in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Neurobiol Aging 2013; 34(2): 400-407.

    9. Benjamin P, Lawrence AJ, Lambert C, Patel B, Chung AW, MacKinnon AD et al. Strategic lacunes and their relationship to cognitive impairment in cerebral small vessel disease. Neuroimage-Clin 2014; 4: 828-837.

    12. O'Sullivan M, Barrick TR, Morris RG, Clark CA, Markus HS. Damage within a network of white matter regions underlies executive dysfunction in CADASIL. Neurology 2005; 65(10): 1584-1590.

  • Related Research Results (1)
  • Metrics
    No metrics available
Share - Bookmark