Oxacillin sensitization of methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus pseudintermedius by antisense peptide nucleic acids in vitro.

Article English OPEN
Goh, S.; Loeffler, A.; Lloyd, D. H.; Nair, S. P.; Good, L.; (2015)
  • Publisher: BioMed Central
  • Journal: BMC Microbiology,volume 15 (issn: 1471-2180, eissn: 1471-2180)
  • Related identifiers: pmc: PMC4642645, doi: 10.1186/s12866-015-0599-x
  • Subject: MRSA | Research Article | mecA | ftsZ | Methicillin-resistant Staphylococcus pseudintermedius | Antisense, mecA, ftsZ, MRSA, Methicillin-resistant Staphylococcus pseudintermedius | Microbiology (medical) | Antisense
    mesheuropmc: biochemical phenomena, metabolism, and nutrition

Background Antibiotic resistance genes can be targeted by antisense agents, which can reduce their expression and thus restore cellular susceptibility to existing antibiotics. Antisense inhibitors can be gene and pathogen specific, or designed to inhibit a group of bact... View more
  • References (45)
    45 references, page 1 of 5

    1. Fair RJ, Tor Y. Antibiotics and bacterial resistance in the 21st century. Perspect Med Chem. 2014;6:25-64.

    2. McCarthy AJ, Harrison EM, Stanczak-Mrozek K, Leggett B, Waller A, Holmes MA, et al. Genomic insights into the rapid emergence and evolution of MDR in Staphylococcus pseudintermedius. J Antimicrob Chemother. 2014; 70(4):997-1007.

    3. Huber J, Donald RG, Lee SH, Jarantow LW, Salvatore MJ, Meng X, et al. Chemical genetic identification of peptidoglycan inhibitors potentiating carbapenem activity against methicillin-resistant Staphylococcus aureus. Chem Biol. 2009;16:837-48.

    4. Therien AG, Huber JL, Wilson KE, Beaulieu P, Caron A, Claveau D, et al. Broadening the spectrum of beta-lactam antibiotics through inhibition of signal peptidase type I. Antimicrob Agents Chemother. 2012;56:4662-70.

    5. Good L, Stach JE. Synthetic RNA silencing in bacteria-antimicrobial discovery and resistance breaking. Front Microbiol. 2011;2:185.

    6. Moran GJ, Krishnadasan A, Gorwitz RJ, Fosheim GE, McDougal LK, Carey RB, et al. Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med. 2006;355:666-74.

    7. Hughes LA, Williams N, Clegg P, Callaby R, Nuttall T, Coyne K, et al. Crosssectional survey of antimicrobial prescribing patterns in UK small animal veterinary practice. Prev Vet Med. 2012;104:309-16.

    8. Pate AJ, Terribilini RG, Ghobadi F, Azhir A, Barber A, Pearson JM, et al. Antibiotics for methicillin-resistant Staphylococcus aureus skin and soft tissue infections: the challenge of outpatient therapy. Am J Emerg Med. 2014;32: 135-8.

    9. Paul NC, Moodley A, Ghibaudo G, Guardabassi L. Carriage of methicillinresistant Staphylococcus pseudintermedius in small animal veterinarians: indirect evidence of zoonotic transmission. Zoonoses Public Health. 2011;58:533-9.

    10. Starlander G, Borjesson S, Gronlund-Andersson U, Tellgren-Roth C, Melhus A. Cluster of infections caused by methicillin-resistant Staphylococcus pseudintermedius in humans in a tertiary hospital. J Clin Microbiol. 2014;52:3118-20.

  • Related Research Results (3)
  • Metrics
    No metrics available
Share - Bookmark