Improving Mitochondrial Function Protects Bumblebees from Neonicotinoid Pesticides

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Powner, Michael B. ; Salt, Thomas E. ; Hogg, Chris ; Jeffery, Glen (2016)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 11, issue 11 (eissn: 1932-6203)
  • Related identifiers: pmc: PMC5112779, doi: 10.1371/journal.pone.0166531
  • Subject: Energy-Producing Organelles | Research Article | Population Metrics | Ecology and Environmental Sciences | Agriculture | Ecology | SF | Physical Sciences | Bioenergetics | Agrochemicals | People and Places | Demography | Pesticides | Physics | Animals | Insecticides | Pest Control | Bees | Biology and Life Sciences | Mitochondria | Agroecology | Arthropoda | Physiology | Insects | Population Biology | Cell Biology | Electromagnetic Radiation | Electrophysiology | Cellular Structures and Organelles | Light | Hymenoptera | Biochemistry | Membrane Potential | Organisms | Death Rates | Medicine and Health Sciences | Invertebrates | Colony Collapse
    mesheuropmc: fungi

Global pollination is threatened by declining insect pollinator populations that may be linked to neonicotinoid pesticide use. Neonicotinoids over stimulate neurons and depolarize their mitochondria, producing immobility and death. However, mitochondrial function can be improved by near infrared light absorbed by cytochrome c oxidase in mitochondrial respiration. In flies, daily exposure to 670nm light throughout life increases average lifespan and aged mobility, and reduces systemic inflammation. Here we treat bumble bees with Imidacloprid a common neonicotinoid. This undermined ATP and rapidly induced immobility and reduced visual function and survival. Bees exposed to insecticide and daily to 670nm light showed corrected ATP levels and significantly improved mobility allowing them to feed. Physiological recordings from eyes revealed that light exposure corrected deficits induced by the pesticide. Overall, death rates in bees exposed to insecticide but also given 670nm light were indistinguishable from controls. When Imidacloprid and light exposure were withdrawn, survival was maintained. Bees and insects generally cannot see deep red light so it does not disturb their behaviour. Hence, we show that deep red light exposure that improves mitochondrial function, reverses the sensory and motor deficits induced by Imidacloprid. These results may have important implications as light delivery is economic and can be placed in hives/colonies.
  • References (20)
    20 references, page 1 of 2

    1. Goulson D (2013) An overview of the environmental risks posed by neonicotinoid insecticides. J.Appl. Ecol. 50: 977±987.

    2. Moffat C, Pacheco JG, Sharp S, Samson AJ, Bollan KA, Huang J, et al. (2015) Chronic exposure to neonicotinoids increases neuronal vulnerability to mitochondrial dysfunction in the bumblebee (Bombus terrestris). FASEB J. 29: 2112±2119. doi: 10.1096/fj.14-267179 PMID: 25634958

    3. Moffat C, Buckland ST, Samson AJ, McArthur R, Chamosa Pino V, Bolland KA, et al. (2015) Neonicotinoids target distinct nicotinic acetylcholine recpetors and neurons, leading to differential risks to bumblebees. Sci. Rep. 6:24764. 1±10.

    4. Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013) The hallmarks of aging. Cell. 153: 1194±1217. doi: 10.1016/j.cell.2013.05.039 PMID: 23746838

    5. Vernace VA, Arnaund L, Schmidt-Glenewinkel T, Figueiredo-Pereira (2016) Aging perturbs 26S proteasome assembly in Drosophila melanogaster. FASEB J. 21: 2672±2682.

    6. Ferguson M, Mockett RJ, Shen Yi, Orr WC, Sohal RS (2005) Age associated decline in mitochondrial respiration and electron transport in Drosophila melanogaster. Biochem. J. 390: 501±511. doi: 10.1042/ BJ20042130 PMID: 15853766

    7. Tait SWG, Green DR (2010) Mitochondria and cell death: outer membrane permeabilization and beyond. Nature Revs. Mol. Cell Biol. 11: 621±632.

    Wilson M, Greenwood C (1970) The long wavelength absorption band of cytochrome c oxidase. Biochem. J. 116: 17±18.

    9. Karu TI (2008) Mitochondrial signaling in mammalian cells activated by red and near-IR radiation. Photochem. Photobiol. 84: 1091±1099. doi: 10.1111/j.1751-1097.2008.00394.x PMID: 18651871

    10. Rojas J, Gonzalaez-Lima (2011) Low-level light therapy of the eye and brain. Eye and Brain. Dovepress 3: 49±67.

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