Core-sheath nanofibers as drug delivery system for thermoresponsive controlled release

Article English OPEN
Lv, Y. ; Pan, Q. ; Bligh, S.W.A. ; Li, H. ; Wu, H ; Sang, Qingqing ; Zhu, Li-Min (2017)

In this work, a smart drug delivery system of core–sheath nanofiber is reported. The core-sheath nanofibers were prepared with thermoresponsive poly-(N-isopropylacrylamide) (PNIPAAm) (as core) and hydrophobic ethylcellulose (EC) (as sheath) by coaxial electrospinning. Analogous medicated fibers were prepared by loading with a model drug ketoprofen (KET). The fibers were cylindrical without phase separation and have visible core-sheath structure as shown by scanning and transmission electron microscopy. X-ray diffraction patterns demonstrated the drug with the amorphous physical form was present in the fiber matrix. Fourier transform infrared spectroscopy analysis was conducted, finding that there were significant intermolecular interactions between KET and the polymers. Water contact angle measurements proved that the core-sheath fibers from hydrophobic transformed into hydrophobic when the temperature reached the lower critical solution temperature. In vitro drug-release study of nanofibers with KET displayed that the coaxial nanofibers were able to synergistically combine the characteristics of the two polymers producing a temperature-sensitive drug delivery system with sustained release properties. In addition, they were established to be non-toxic and suitable for cell growth. These findings show that the core–sheath nanofiber is a potential candidate for controlling drug delivery system.
  • References (16)
    16 references, page 1 of 2

    [1] Yang T, Yao Y, Lin Y, et al. Electrospinning of polyacrylonitrile fibers from ionic liquid solution. Appl Phys A, 2010, 98(3):517-523.

    [2] Jin W J, Jeon H J, Kim J H, et al. A study on the preparation of poly(vinyl alcohol) nanofibers containing silver nanoparticles. Synth Met, 2007, 157(10-12):454-459.

    [3] Min B M, Lee G, Kim S H, et al. Electrospinning of silk fibroin nanofibers and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro. Biomaterials, 2004, 25(7-8):1289-1297.

    [4] Li X, Qian Q, Zheng W, et al. Preparation and Characteristics of LaOCl Nanotubes by Coaxial Electrospinning. Mater Lett, 2012, 80(8):43-45.

    [5] Wang B, Zhang P P, Williams G R, et al. A simple route to form magnetic chitosan nanoparticles from coaxial-electrospun composite nanofibers. J Mater Sci, 2013, 48(11):3991-3998.

    [6] Zander N E. Hierarchically Structured Electrospun Fibers. Polymers, 2013, 5(1):19-44.

    [7] Fu Y, Guan J, Guo S, et al. Human urine-derived stem cells in combination with polycaprolactone/gelatin nanofibrous membranes enhance wound healing by promoting angiogenesis. J Transl Med, 2013, 12(1):1-14.

    [8] Christina K, Alessandra A, Alessandra A, et al. Fabrication, functionalization, and application of electrospun biopolymer nanofibers. Crit Rev Food Sci Nutr, 2008, 48(8):775-797.

    [9] Hedges A R. The Application of Soft-Calender. Chem Rev, 1998, 98(98):2035-2044.

    [10] Qiu S, Liu L, Wang B, et al. Facile Synthesis of Carbazole-Containing Semiladder Polyphenylenes for Pure-Blue Electroluminescence. Macromolecules, 2005, 38(16):6782-6788.

  • Similar Research Results (1)
  • Metrics
    0
    views in OpenAIRE
    0
    views in local repository
    9
    downloads in local repository

    The information is available from the following content providers:

    From Number Of Views Number Of Downloads
    WestminsterResearch - IRUS-UK 0 9
Share - Bookmark