Effect of cellular aging on fibroblastic phenotype and regulation by hyaluronan

Doctoral thesis English OPEN
Simpson, Russell Michael
  • Subject: R1

Collectively, the data demonstrated that HA can serve as a signal integrator by facilitating TGF-beta11-mediated CD44-EGF-R-ERK interactions and ultimately regulate fibroblast phenotype. I propose a model to explain this novel mechanism and the functional consequence of age-dependent dysregulation. This mechanism may have direct implications for modifying the wound healing response, particularly for developing therapeutic strategies to improve healing in the elderly
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