publication . Article . Other literature type . 2013

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Berndt, S.I.; Skibola, C.F.; Joseph, V.; Camp, N.J.; Nieters, A.; Wang, Z.; Cozen, W.; Monnereau, A.; Wang, S.S.; Kelly, R.S.; ...
Open Access
  • Published: 16 Jun 2013
  • Publisher: Nature Publishing Group
Abstract
Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 × 10-14), 18q21.33 (BCL2, P = 7.76 × 10-11), 11p15.5 (C11orf21, P = 2.15 × 10 -10), 4q25 (LEF1, P = 4.24 × 10-10), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 × 10-9), 9p21...
Subjects
free text keywords: Leucèmia limfocítica crònica, Genòmica, Chronic lymphocytic leukemia, Genomics, Case-Control Studies, Chromosomes, Human, Pair 2, Genetic Loci, Genetic Predisposition to Disease, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Polymorphism, Single Nucleotide, Recombination, Genetic, Risk, Genetics, Biology, Locus (genetics), Genome-wide association study, Linkage disequilibrium, Case-control study, medicine.disease, medicine, B-cell lymphoma, Genetic association, Molecular biology, Single-nucleotide polymorphism, Article, Genome-wide association studies (GWAS), chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL)
63 references, page 1 of 5

Albright, F, Teerlink, C, Werner, TL, Cannon-Albright, LA. Significant evidence for a heritable contribution to cancer predisposition: a review of cancer familiality by site. BMC cancer. 2012; 12: 138 [OpenAIRE] [PubMed]

Goldin, LR, Bjorkholm, M, Kristinsson, SY, Turesson, I, Landgren, O. Elevated risk of chronic lymphocytic leukemia and other indolent non-Hodgkin’s lymphomas among relatives of patients with chronic lymphocytic leukemia. Haematologica. 2009; 94: 647-53 [OpenAIRE] [PubMed]

Di Bernardo, MC. A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. Nature genetics. 2008; 40: 1204-10 [PubMed]

Crowther-Swanepoel, D. Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk. Nature genetics. 2010; 42: 132-6 [OpenAIRE] [PubMed]

Slager, SL. Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL. Blood. 2011; 117: 1911-6 [OpenAIRE] [PubMed]

Slager, SL. Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia. Blood. 2012

Park, JH. Estimation of effect size distribution from genome-wide association studies and implications for future discoveries. Nature genetics. 2010; 42: 570-5 [OpenAIRE] [PubMed]

Wang, Z. Improved imputation of common and uncommon SNPs with a new reference set. Nature genetics. 2012; 44: 6-7 [OpenAIRE] [PubMed]

Conde, L. Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. Nature genetics. 2010; 42: 661-4 [OpenAIRE] [PubMed]

Consortium, GP. A map of human genome variation from population-scale sequencing. Nature. 2010; 467: 1061-1073 [OpenAIRE] [PubMed]

Howie, BN, Donnelly, P, Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS genetics. 2009; 5: e1000529 [OpenAIRE] [PubMed]

Crowther-Swanepoel, D. Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk. British journal of haematology. 2011; 154: 229-33 [PubMed]

Rafnar, T. Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nature genetics. 2009; 41: 221-7 [OpenAIRE] [PubMed]

Shete, S. Genome-wide association study identifies five susceptibility loci for glioma. Nature genetics. 2009; 41: 899-904 [OpenAIRE] [PubMed]

McKay, JD. Lung cancer susceptibility locus at 5p15.33. Nature genetics. 2008; 40: 1404-6 [OpenAIRE] [PubMed]

63 references, page 1 of 5
Abstract
Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 × 10-14), 18q21.33 (BCL2, P = 7.76 × 10-11), 11p15.5 (C11orf21, P = 2.15 × 10 -10), 4q25 (LEF1, P = 4.24 × 10-10), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 × 10-9), 9p21...
Subjects
free text keywords: Leucèmia limfocítica crònica, Genòmica, Chronic lymphocytic leukemia, Genomics, Case-Control Studies, Chromosomes, Human, Pair 2, Genetic Loci, Genetic Predisposition to Disease, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Polymorphism, Single Nucleotide, Recombination, Genetic, Risk, Genetics, Biology, Locus (genetics), Genome-wide association study, Linkage disequilibrium, Case-control study, medicine.disease, medicine, B-cell lymphoma, Genetic association, Molecular biology, Single-nucleotide polymorphism, Article, Genome-wide association studies (GWAS), chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL)
63 references, page 1 of 5

Albright, F, Teerlink, C, Werner, TL, Cannon-Albright, LA. Significant evidence for a heritable contribution to cancer predisposition: a review of cancer familiality by site. BMC cancer. 2012; 12: 138 [OpenAIRE] [PubMed]

Goldin, LR, Bjorkholm, M, Kristinsson, SY, Turesson, I, Landgren, O. Elevated risk of chronic lymphocytic leukemia and other indolent non-Hodgkin’s lymphomas among relatives of patients with chronic lymphocytic leukemia. Haematologica. 2009; 94: 647-53 [OpenAIRE] [PubMed]

Di Bernardo, MC. A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. Nature genetics. 2008; 40: 1204-10 [PubMed]

Crowther-Swanepoel, D. Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk. Nature genetics. 2010; 42: 132-6 [OpenAIRE] [PubMed]

Slager, SL. Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL. Blood. 2011; 117: 1911-6 [OpenAIRE] [PubMed]

Slager, SL. Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia. Blood. 2012

Park, JH. Estimation of effect size distribution from genome-wide association studies and implications for future discoveries. Nature genetics. 2010; 42: 570-5 [OpenAIRE] [PubMed]

Wang, Z. Improved imputation of common and uncommon SNPs with a new reference set. Nature genetics. 2012; 44: 6-7 [OpenAIRE] [PubMed]

Conde, L. Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. Nature genetics. 2010; 42: 661-4 [OpenAIRE] [PubMed]

Consortium, GP. A map of human genome variation from population-scale sequencing. Nature. 2010; 467: 1061-1073 [OpenAIRE] [PubMed]

Howie, BN, Donnelly, P, Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS genetics. 2009; 5: e1000529 [OpenAIRE] [PubMed]

Crowther-Swanepoel, D. Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk. British journal of haematology. 2011; 154: 229-33 [PubMed]

Rafnar, T. Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nature genetics. 2009; 41: 221-7 [OpenAIRE] [PubMed]

Shete, S. Genome-wide association study identifies five susceptibility loci for glioma. Nature genetics. 2009; 41: 899-904 [OpenAIRE] [PubMed]

McKay, JD. Lung cancer susceptibility locus at 5p15.33. Nature genetics. 2008; 40: 1404-6 [OpenAIRE] [PubMed]

63 references, page 1 of 5
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publication . Article . Other literature type . 2013

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Berndt, S.I.; Skibola, C.F.; Joseph, V.; Camp, N.J.; Nieters, A.; Wang, Z.; Cozen, W.; Monnereau, A.; Wang, S.S.; Kelly, R.S.; ...