Recent advances in drug delivery systems based on polypeptides prepared from N-carboxyanhydrides

Review, Article English OPEN
Hehir, Sarah ; Cameron, Neil R. (2014)
  • Publisher: WILEY-BLACKWELL
  • Journal: POLYMER INTERNATIONAL, volume 63, issue 6, pages 943-954 (issn: 0959-8103)
  • Related identifiers: doi: 10.1002/pi.4710
  • Subject: RS | TP

Recent years have seen a dramatic increase in interest in the use of ring-opening polymerization of N-carboxyanhydride monomers as a method to prepare well-defined polypeptides and peptide hybrid materials. The resulting molecules are often capable of assembling into a variety of different structures, including micelles, vesicles, nanoparticles and hydrogels, and therefore have been explored as novel drug delivery systems. Peptides are attractive in this regard due to their rich chemical functionality and ability to assemble through the formation of secondary structures (e.g. α-helices and β-sheets). In addition, they are inherently biodegradable and biocompatible. This review describes recent advances in the field, covering aspects such as improved methods with which to prepare better-defined polypeptides, crosslinking of assemblies to enhance biostability, the preparation of materials that respond to a variety of stimuli (including light and intra- or extracellular redox conditions), functionalization with targeting ligands to enhance cellular uptake, assemblies for small interfering RNA delivery and approaches to theranostic systems. © 2014 Society of Chemical Industry\ud
  • References (15)
    15 references, page 1 of 2

    1. Blanazs A, Armes SP and Ryan AJ Macromol Rapid Commun 30: 267-277 (2009).

    2. Carlsen A and Lecommandoux S Curr Opinion Colloid Interf Sci 14: 329-339 (2009).

    3. Kricheldorf HR Angew Chem Int Ed 45: 5752 - 5784 (2006).

    4. Cheng J and Deming TJ Top Curr Chem 1: 310 (2012).

    5. Habraken GJM, Heise A and Thornton PD Macromol Rapid Commun 33: 272−286 (2011).

    6. Morell M and Puiggalí J Polymers 5: 188-224 (2013).

    7. Osada K, Christie RJ and Kataoka K J Roy Soc Interface 6: S325-S339 (2009).

    8. Li W, Yoon JA and Matyjaszewski K J Am Chem Soc 132: 7823-7825 (2010).

    9. Trivedi R and Kompella UB Nanomedicine 5: 485-505 (2010).

    10. Oerlemans C, Bult W, Bos M, Storm G, Nijsen JFW and Hennink WE Pharm Res 27: 2569- 2589 (2010).

  • Metrics
    No metrics available
Share - Bookmark