The incidence of dementia in England and Wales: findings from the five identical sites of the MRC CFA Study.

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Matthews, F. ; Brayne, C. ; Medical Research Council, Cognitive Function and Ageing Study Investigators (2005)
  • Publisher: Public Library of Science

Background: Although incidence of dementia is known to vary between nations, variation within country has not been explored because most incidence studies are single site or have insufficient numbers to compare sites. Few countries have conducted multisite incidence studies in order to facilitate national comparisons. This study aims to provide robust measures of the variation of the incidence of dementia across sites within England and Wales and produce overall estimates by age and sex. \ud \ud Methods and findings: The Medical Research Council Cognitive Function and Ageing Study used identical methodology in five diverse sites across the United Kingdom, each with different risk patterns and mortality rates. Incidence has been estimated using likelihood-based methods between the first two waves of interviews. Incidence rates rise with age, particularly above the age of 75 y, from 6.7 [corrected] (95% confidence interval, 3.8 [corrected]-12.4 [corrected]) per 1,000 person years at age 65-69 y to 68.5 [corrected] (95% confidence interval, 52.5 [corrected]-88.1 [corrected]) per 1,000 person years at age 85 y and above. The rate of increase for both sexes is marked, and continues into the oldest age groups. Hence, it is estimated that approximately 163,000 [corrected] new cases of dementia occur in England and Wales each year. There is no convincing evidence of variation across sites, and incidence rates do not reflect the variations in the prevalence of possible risk factors in these sites. \ud \ud Conclusion: There is no evidence, within England and Wales, of variation in dementia incidence across sites. Dementia incidence rates do not tail off at the oldest ages.
  • References (52)
    52 references, page 1 of 6

    1. Ott A, Breteler MM, van Harskamp F, Stijnen T, Hofman A (1998) Incidence and risk of dementia. The Rotterdam Study. Am J Epidemiol 147: 574-580.

    2. Bachman DL, Wolf PA, Linn RT, Knoefel JE, Cobb JL, et al. (1993) Incidence of dementia and probable Alzheimer's disease in a general population: The Framingham Study. Neurology 43: 515-519.

    3. Hebert LE, Scherr PA, Beckett LA, Albert MS, Pilgrim DM, et al. (1995) Agespecific incidence of Alzheimer's disease in a community population. JAMA 273: 1354-1359.

    4. Miech RA, Breitner JC, Zandi PP, Khachaturian AS, Anthony JC, et al. (2002) Incidence of AD may decline in the early 90s for men, later for women: The Cache County study. Neurology 58: 209-218.

    5. Canadian Study of Health and Aging Working Group (2000) The incidence of dementia in Canada. The Canadian Study of Health and Aging Working Group. Neurology 55: 66-73.

    6. Di Carlo A, Baldereschi M, Amaducci L, Lepore V, Bracco L, et al. (2002) Incidence of dementia, Alzheimer's disease, and vascular dementia in Italy. The ILSA Study. J Am Geriatr Soc 50: 41-48.

    7. Kukull WA, Ganguli M (2000) Epidemiology of dementia: Concepts and overview. Neurol Clin 18: 923-950.

    8. Evans DA, Bennett DA, Wilson RS, Bienias JL, Morris MC, et al. (2003) Incidence of Alzheimer disease in a biracial urban community: Relation to apolipoprotein E allele status. Arch Neurol 60: 185-189.

    9. Tang MX, Cross P, Andrews H, Jacobs DM, Small S, et al. (2001) Incidence of AD in African-Americans, Caribbean Hispanics, and Caucasians in northern Manhattan. Neurology 56: 49-56.

    10. Hendrie HC, Ogunniyi A, Hall KS, Baiyewu O, Unverzagt FW, et al. (2001) Incidence of dementia and Alzheimer disease in 2 communities: Yoruba residing in Ibadan, Nigeria, and African Americans residing in Indianapolis, Indiana. JAMA 285: 739-747.

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