Design and synthesis of triplex metallohelices
Faulkner, Alan D.
Chapter 1 introduces the concept of π-stacking. Different literature interpretations based on both model systems and theoretical observation are discussed.\ud \ud Chapter 2 describes how π-stacking interactions in a series of [ZnLn3]2+ complexes are affected by the incorporation of ring substituents by focusing on the fac:mer selectivity of these systems. The stability of Fe(II) complexes to undergo further functionalization post complexation is also investigated, in particular their ability to undergo copper(I)-catalysed Huisgen 1,3-dipolar cycloaddition 'click' reactions.\ud \ud Chapter 3 focuses on the use of inter-ligand π-stacking interactions in the formation of asymmetric, bimetallic coordination complexes that we have termed triplexes metallohelices. The selectivity of these systems has been investigated by computational means. The structure has been confirmed by both solution and solid state measurement. In addition the inherent stability of these complexes to functionalization, both pre and post complexation, is also discussed.\ud \ud Chapter 4 focuses on the synthesis of water soluble variants of triplex metallohelices and their potential biological applications. In particular their anti-cancer properties are presented in detail.\ud \ud Chapter 5 details the experimental procedures used to carry out the work in this thesis.