Lymphatic filariasis mapping by Immunochromatographic Test cards and baseline microfilaria survey prior to mass drug administration in Sierra Leone

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Koroma, Joseph ; Bangura, Momodu M ; Hodges, Mary H ; Bah, Mohamed ; Zhang, Yaobi ; Bockarie, Moses (2012)
  • Publisher: BioMed Central
  • Journal: Parasites & Vectors, volume 5, pages 10-10 (issn: 1756-3305, eissn: 1756-3305)
  • Related identifiers: pmc: PMC3268710, doi: 10.1186/1756-3305-5-10
  • Subject: wc_880 | RC109-216 | wb_710 | Infectious Diseases | Infectious and parasitic diseases | wb_340 | Research | qy_250 | Parasitology
    mesheuropmc: parasitic diseases

<p>Abstract</p> <p>Background</p> <p>National mapping of lymphatic filariasis (LF) was conducted using Immunochromatographic tests (ICT) in 2005 to determine endemicity and geographic spread of the disease. A baseline microfilaria survey was then conducted to determine LF prevalence and microfilaria intensity.</p> <p>Methods</p> <p>In 2005 1,982 persons of 15 years and over from 14 health districts were selected and fingertip blood samples were tested with ICT cards. In 2007-8 blood samples were taken between 10 p.m. and 2 a.m. and examined for microfilaria (mf) from 9,288 persons from 16 sentinel sites representing each district and 2 additional sites for districts with populations over 500,000 (Bo and Kenema).</p> <p>Results</p> <p>The overall LF prevalence by ICT cards was 21% (males 28%, females 15%). All districts had a prevalence of <it>Wuchereria bancrofti </it>antigen > 1%. Distribution of LF prevalence showed a strong spatial correlation pattern with high prevalence in a large area in the northeast gradually decreasing to a relatively low prevalence in the southwest coast. High prevalence was found in the northeast, Bombali (52%), Koinadugu (46%), Tonkolili (37%) and Kono (30%). Low prevalence was found in the southwest, Bonthe (3%) and Pujehun (4%). The mf prevalence was higher in the northeast: Bombali, 6.7%, Koinadugu 5.7%, Port Loko 4.4% and Kono 2.4%. Overall there was a significant difference in mf prevalence by gender: males 2.9%, females 1.8% (p = 0.0002) and within districts in Kailahun, Kono, Port Loko, Moyamba and Koinadugu (all p < 0.05). The mf prevalence was higher in people > 20 years (2.5%) than in people ≤ 20 years (1.7%) (p = 0.043). The overall arithmetic mean mf density was 50.30 mf/ml among mf-positive individuals and 1.19 mf/ml in the population examined which varied significantly between districts.</p> <p>Conclusions</p> <p>The ICT results showed that LF was endemic nationwide and that preventive chemotherapy (PCT) was justified across the country. Both the ICT and microfilaraemia surveys found that prevalence was greater in males than females. The increase in microfilaraemia prevalence by age was evident when grouped as ≤ 20 versus > 20 years demonstrating early exposure. Baseline LF microfilaria load will be used to monitor PCT program progress.</p>
  • References (43)
    43 references, page 1 of 5

    1. Melrose WD: Lymphatic filariasis: A review 1862-2002 Killarney-Australia: Warwick Educational Publishing Inc.; 2004.

    2. Bockarie MJ, Molyneux DH: The end of lymphatic filariasis? BMJ 2009, 338: b1686.

    3. Ottesen EA, Duke BO, Karam M, Behbehani K: Strategies and tools for the control/elimination of lymphatic filariasis. Bull World Health Organ 1997, 75(6):491-503.

    4. Molyneux DH, Taylor MJ: Current status and future prospects of the Global Lymphatic Filariasis Programme. Curr Opin Infect Dis 2001, 14(2):155-159.

    5. Kelly-Hope LA, Diggle PJ, Rowlingson BS, Gyapong JO, Kyelem D, Coleman M, Thomson MC, Obsomer V, Lindsay SW, Hemingway J, et al: Short communication: Negative spatial association between lymphatic filariasis and malaria in West Africa. Trop Med Int Health 2006, 11(2):129-135.

    6. Ottesen EA: Lymphatic filariasis: Treatment, control and elimination. Adv Parasitol 2006, 61:395-441.

    7. Ottesen EA, Hooper PJ, Bradley M, Biswas G: The global programme to eliminate lymphatic filariasis: health impact after 8 years. PLoS Negl Trop Dis 2008, 2(10):e317.

    8. Dunyo SK, Appawu M, Nkrumah FK, Baffoe-Wilmot A, Pedersen EM, Simonsen PE: Lymphatic filariasis on the coast of Ghana. Trans R Soc Trop Med Hyg 1996, 90(6):634-638.

    9. Okon OE, Iboh CI, Opara KN: Bancroftian filariasis among the Mbembe people of Cross River state, Nigeria. J Vector Borne Dis 2010, 47(2):91-96.

    10. Lymphatic filariasis: the disease and its control. Fifth report of the WHO Expert Committee on Filariasis. World Health Organ Tech Rep Ser 1992, 821:1-71.

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