A review of the differences between normal and osteoarthritis articular cartilage in human knee and ankle joints

Article English OPEN
Hendren, Linda ; Beeson, Paul ; The University of Northampton (2009)

Background: Osteoarthritis (OA) is the most common joint disease yet its pathophysiology is still poorly understood. It is more prevalent in some lower limb joints than others; in particular the knee is more commonly affected than the ankle. Research into articular cartilage and OA has primarily focussed on using animal models. However, it is apparent that articular cartilage differs between species, so more research is concentrating on human cartilage.\ud Objective: This paper reviews recent studies that have been undertaken to elucidate the reasons for this, and to discover if the findings would alter the conception that articular cartilage is not capable of repair. Method: Primary research papers into human knee and ankle cartilage published since 1997 have been reviewed.\ud Results: Differences in the structure, metabolism, physical properties and response to trauma have been found, implying that ankle cartilage may be more resistant to damage.\ud Conclusions: More research is needed before definitive conclusions can be reached, but the findings so far suggest that OA should not be accepted as the inevitable outcome of joint injury and individuals and practitioners, such as podiatrists, may be able to use simple measures to prevent or delay its onset
  • References (14)
    14 references, page 1 of 2

    1. Buckwalter JA, Mankin HJ. Articular cartilage. Part II: Degeneration and osteoarthrosis, repair, regeneration and transplantation. The Journal of Bone and Joint Surgery. 1997; 79-A(4): 612-632.

    2. Treppo S, Koepp H, Quan EC, Cole AA, Kuettner KE, Grodzinsky AJ. Comparison of biomechanical and biochemical properties of cartilage from human knee and ankle pairs. Journal of Orthopaedic Research. 2000; 18: 739-748.

    3. Huch K. Knee and ankle: human joints with different susceptibility to osteoarthritis reveal different cartilage cellularity and matrix synthesis in vitro. Archives of Orthopaedic and Trauma Surgery. 2001; 121: 301-306.

    4. Huch K, Kuettner KE, Dieppe P. Osteoarthritis in knee and ankle joints. Seminars in Arthritis and Rheumatism. 1997; 26(4): 667-674.

    6. Kuettner KE, Cole, AA. Cartilage degeneration in different human joints. Osteoarthritis and Cartilag.e 2005; 13: 93-103.

    7. Buckwalter JA, Mankin HJ. Articular cartilage. Part I: Tissue design and chondrocyte-matrix interactions. The Journal of Bone and Joint Surgery. 1997; 79- A(4): 600-611.

    8. Aigner T, Stöve J. Collagens - major component of the physiological matrix, major target of cartilage degeneration, major tool in cartilage repair. Advanced Drug Delivery Reviews. 2003; 55: 1569-1593.

    9. Muldrew . Osteoarthritis as an inevitable consequence of the structure of articular cartilage. Medical Hypotheses. 2002; 59(4): 389-397.

    10. Arden N, Nevitt MC. Osteoarthritis: Epidemiology. Best Practice and Research Clinical Rheumatology. 2006; 20(1): 3-25.

    11. Newman AB, Haggerty CL, Goodpaster B, Harris T, Kritchevsky S, Nevitt M, Miles TP, Visser M. Strength and muscle quality in a well-functioning cohort of older adults: the health, aging and body composition study. Journal of the American Geriatrics Societ. 2003; 51: 323-330.

  • Metrics
    views in OpenAIRE
    views in local repository
    downloads in local repository

    The information is available from the following content providers:

    From Number Of Views Number Of Downloads
    NECTAR - IRUS-UK 0 54
Share - Bookmark