TopoGSA: network topological gene set analysis

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Glaab, Enrico ; Baudot, Anais ; Krasnogor, Natalio ; Valencia, Alfonso (2010)
  • Publisher: Oxford University Press
  • Journal: volume 26, issue 9, pages 1,271-1,272 (issn: 1367-4803, eissn: 1367-4811)
  • Related identifiers: doi: 10.1093/bioinformatics/btq131, pmc: PMC2859135
  • Subject: Systems Biology | : Biochemistry, biophysics & molecular biology [F05] [Life sciences] | : Biochimie, biophysique & biologie moléculaire [F05] [Sciences du vivant] | Applications Note

Summary: TopoGSA (Topology-based Gene Set Analysis) is a web-application dedicated to the computation and visualization of network topological properties for gene and protein sets in molecular interaction networks. Different topological characteristics, such as the centrality of nodes in the network or their tendency to form clusters, can be computed and compared with those of known cellular pathways and processes. Availability: Freely available at http://www.infobiotics.net/topogsa Contact: nxk@cs.nott.ac.uk; avalencia@cnio.es
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