Chicken blood provides a suitable meal for the sand fly Lutzomyia longipalpis and does not inhibit Leishmania development in the gut

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Sant'anna, Mauricio Rv ; Nascimento, Alexandre ; Alexander, Bruce ; Dilger, Erin ; Cavalcante, Reginaldo R ; Diaz-Albiter, Hector M ; Bates, Paul A ; Dillon, Rod J (2010)
  • Publisher: BioMed Central
  • Journal: volume 3, pages 3-3 (eissn: 1756-3305)
  • Related identifiers: doi: 10.1186/1756-3305-3-3, pmc: PMC2823724
  • Subject: qx_650 | Infectious Diseases | qx_45 | Research | Parasitology
    mesheuropmc: embryonic structures | parasitic diseases | animal structures

BACKGROUND\ud \ud The aim of this study was to address the role of chickens as bloodmeal sources for female Lutzomyia longipalpis and to test whether chicken blood is harmful to Leishmania parasite development within the sand flies. Bloodmeal ingestion, excretion of urate, reproduction, fecundity, as well as Leishmania infection and development were compared in sand flies fed on blood from chickens and different mammalian sources.\ud \ud RESULTS\ud \ud Large differences in haemoglobin and protein concentrations in whole blood (dog>human>rabbit> chicken) did not correlate with differences in bloodmeal protein concentrations (dog = chicken>human>rabbit). This indicated that Lu. longipalpis were able to concentrate bloodmeals taken from different hosts using prediuresis and this was confirmed by direct observation. Sand flies fed on chickens or dogs produced significantly more eggs than those fed on human blood. Female Lu. longipalpis retained significantly more urate inside their bodies when fed on chicken blood compared to those fed on rabbit blood. However, when the amounts of urate excreted after feeding were measured, sand flies fed on rabbit blood excreted significantly more than those fed on chicken blood. There was no difference in female longevity after feeding on avian or mammalian blood.Sand flies infected via chicken blood produced Leishmania mexicana infections with a similar developmental pattern but higher overall parasite populations than sand flies infected via rabbit blood. \ud \ud CONCLUSIONS\ud \ud The results of this study help to define the role that chickens play in the epidemiology of leishmaniasis. The present study using a Lu. longipalpis/L. mexicana model indicates that chickens are suitable hosts to support a Lu. longipalpis population and that chicken blood is likely to support the development of transmissible Leishmania infections in Lu. longipalpis.
  • References (36)
    36 references, page 1 of 4

    1. Lainson R, Rangel EF: Lutzomyia longipalpis and the eco-epidemiology of American visceral leishmaniasis, with particular reference to Brazil: a review. Mem Inst Oswaldo Cruz 2005, 100:811-827.

    2. Alexander B, de Carvalho RL, McCallum H, Pereira MH: Role of the domestic chicken (Gallus gallus) in the epidemiology of urban visceral leishmaniasis in Brazil. Em Infect Dis 2002, 8:1480-1485.

    3. Michalsky EM, Rocha MF, da Rocha Lima AC, França-Silva JC, Pires MQ, Oliveira FS, Pacheco RS, Dos Santos SL, Barata RA, Romanha AJ, FortesDias CL, Dias ES: Infectivity of seropositive dogs, showing different clinical forms of leishmaniasis, to Lutzomyia longipalpis phlebotomine sand flies. Vet Parasitol 2007, 147:67-76.

    4. Ready PD: Factors affecting egg production of laboratory-bred Lutzomyia longipalpis (Diptera: Psychodidae). J Med Entomol 1979, 16:413-423.

    5. Alder S: Leishmania. Adv Parasitol 1964, 2:35-91.

    6. Schlein Y, Warburg A, Schur LF, Shomai J: Vector compatibility of Phlebotomus papatasti on differentially induced digestion. Acta Trop 1983, 40:65-70.

    7. Corredor A, Gallego JF, Tesh RB, Morales A, De Carrasquilla CF, Young DG, Kreutzer RD, Boshell J, Palau MT, Caceres E: Epidemiology of visceral leishmaniasis in Colombia. Am J Trop Med Hyg 1989, 40:480-486.

    8. Castellon AJ, Domingos ED: On the focus of kala-azar in the state of Roraima, Brazil. Mem Inst Oswaldo Cruz 1991, 86:375.

    9. Arias JR, Monteiro PS, Zucker F: The re-emergence of visceral leishmaniasis in Brazil. Em Infect Dis 1996, 2:145-146.

    10. Caldas AJ, Costa JM, Silvam AA, Vinhas V, Barral A: Risk factors associated with asymptomatic infection by Leishmania chagasi in north-east Brazil. Trans R Soc Trop Med Hyg 2002, 96:21-28.

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