Acoustically controlled enhancement of molecular sensing to assess oxidative stress in cells

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Reboud, J. ; Auchinvole, C. ; Syme, C.D. ; Wilson, R. ; Cooper, J.M. (2013)
  • Publisher: Royal Society of Chemistry
  • Related identifiers: doi: 10.1039/C3CC37931K
  • Subject: QC | TK
    mesheuropmc: otorhinolaryngologic diseases

We demonstrate a microfluidic platform for the controlled aggregation of colloidal silver nanoparticles using surface acoustic waves (SAWs), enabling surface enhanced Raman scattering (SERS) analysis of a cell based model for oxidative damage. We show that by varying the frequency and the power of the acoustic energy, it is possible to modulate the aggregation of the colloid within the sample and hence to optimise the SERS analysis.
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