Combinatorial libraries and the evaluation of diversity

Article English OPEN
Willett, P. (2002)
  • Subject:
    mesheuropmc: respiratory system | human activities

This paper reviews quantitative techniques for the analysis of molecular diversity and the algorithms that are used to select structurally diverse sets of compounds. These procedures are exemplified by a program, called SELECT, which we have developed for the design of structurally diverse, drug-like combinatorial libraries.
  • References (3)

    Perspect Drug Discov Design 1997;7/8:1-180.

    Dean PM, Lewis RA, editors. Molecular diversity in drug design. Dordrecht: Kluwer; 1999.

    Boyd DB, Agrafiotis DK, Martin EJ, editors. Special Issue on combinatorial library design. J Mol Graph Model 2000;18:317-541.

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