Diastereoselective synthesis of P-chirogenic phosphoramidate prodrugs of nucleoside analogues (ProTides) via copper catalysed reaction

Article English OPEN
Pertusati, Fabrizio ; McGuigan, Christopher (2015)
  • Publisher: RSC Publishing
  • Related identifiers: doi: 10.1039/C5CC00448A
  • Subject: QD | RM
    mesheuropmc: inorganic chemicals

The first copper-catalysed diastereoselective synthesis of P-chiral phosphoramidate prodrugs (ProTides) is reported. This procedure allows the synthesis of diastereomeric-enriched mixtures of ProTides. Application of this methodology to the asymmetric phosphorylation of purine and pyrimidine nucleoside analogues is presented.
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