publication . Article . 2008

Formulation of a live bacterial vaccine for stable room temperature storage results in loss of acid, bile and bile salt resistance

Alexander D. Edwards; Nigel K.H. Slater;
Open Access English
  • Published: 23 Oct 2008
  • Publisher: Elsevier
  • Country: United Kingdom
Abstract
Live bacterial vaccines have great promise both as vaccines against enteric pathogens and as heterologous antigen vectors against diverse diseases. Ideally, room temperature stable dry formulations of live bacterial vaccines will allow oral vaccination without cold-chain storage or injections. Attenuated Salmonella can cross the intestinal wall and deliver replicating antigen plus innate immune activation signals directly to the intestinal immune tissues; however, the ingested bacteria must survive firstly gastric acid and secondly the antimicrobial defences of the small intestine. We found that the way in which cells are grown prior to formulation markedly affe...
Subjects
free text keywords: Public Health, Environmental and Occupational Health, General Immunology and Microbiology, Molecular Medicine, General Veterinary, Infectious Diseases, Biology, Salmonella, medicine.disease_cause, medicine, Immune system, Microbiology, Bacterial vaccine, Trehalose, chemistry.chemical_compound, chemistry, Salmonella vaccine, Immunology, Bacteria, biology.organism_classification, Small intestine, medicine.anatomical_structure, Antimicrobial
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publication . Article . 2008

Formulation of a live bacterial vaccine for stable room temperature storage results in loss of acid, bile and bile salt resistance

Alexander D. Edwards; Nigel K.H. Slater;