Suitability of dysphonia measurements for telemonitoring of Parkinson's disease

Other literature type, Article, Unknown English OPEN
Little, Max A. ; McSharry, Patrick E. ; Hunter, Eric J. ; Spielman, Jennifer ; Ramig, Lorraine O. (2009)

We present an assessment of the practical value of existing traditional and non-standard measures for discriminating healthy people from people with Parkinson's disease (PD) by detecting dysphonia. We introduce a new measure of dysphonia, Pitch Period Entropy (PPE), which is robust to many uncontrollable confounding effects including noisy acoustic environments and normal, healthy variations in voice frequency. We collected sustained phonations from 31 people, 23 with PD. We then selected 10 highly uncorrelated measures, and an exhaustive search of all possible combinations of these measures finds four that in combination lead to overall correct classification performance of 91.4%, using a kernel support vector machine. In conclusion, we find that non-standard methods in combination with traditional harmonics-to-noise ratios are best able to separate healthy from PD subjects. The selected non-standard methods are robust to many uncontrollable variations in acoustic environment and individual subjects, and are thus well-suited to telemonitoring applications.
  • References (24)
    24 references, page 1 of 3

    A. E. Lang and A. M. Lozano, "Parkinson's disease - First of two parts," New England Journal of Medicine, vol. 339, pp. 1044-1053, 1998.

    S. K. Van Den Eeden, C. M. Tanner, A. L. Bernstein, R. D. Fross, A. Leimpeter, D. A. Bloch, and L. M. Nelson, "Incidence of Parkinson's disease: Variation by age, gender, and Race/Ethnicity," American Journal of Epidemiology, vol. 157, pp. 1015-1022, 2003.

    D. M. Huse, K. Schulman, L. Orsini, J. Castelli-Haley, S. Kennedy, and G. Lenhart, "Burden of illness in Parkinson's disease," Movement Disorders, vol. 20, pp. 1449-1454, 2005.

    N. Singh, V. Pillay, and Y. E. Choonara, "Advances in the treatment of Parkinson's disease," Progress in Neurobiology, vol. 81, pp. 29-44, 2007.

    C. Ruggiero, R. Sacile, and M. Giacomini, "Home telecare," J Telemed Telecare, vol. 5, pp. 11-7, 1999.

    A. K. Ho, R. Iansek, C. Marigliani, J. L. Bradshaw, and S. Gates, "Speech impairment in a large sample of patients with Parkinson's disease," Behavioural Neurology, vol. 11, pp. 131-137, 1998.

    J. A. Logemann, H. B. Fisher, B. Boshes, and E. R. Blonsky, "Frequency and Co-Occurrence of Vocal-Tract Dysfunctions in Speech of a Large Sample of Parkinson Patients," Journal of Speech and Hearing Disorders, vol. 43, pp. 47-57, 1978.

    J. R. Duffy, Motor speech disorders : substrates, differential diagnosis, and management, 2nd ed.

    St. Louis, Mo.: Elsevier Mosby, 2005.

    S. Sapir, J. L. Spielman, L. O. Ramig, B. H. Story, and C. Fox, "Effects of Intensive Voice Treatment (the Lee Silverman Voice Treatment [LSVT]) on Vowel Articulation in Dysarthric Individuals With Idiopathic Parkinson Disease: Acoustic and Perceptual Findings," J Speech Lang Hear Res, vol. 50, pp. 899-912, 2007.

  • Metrics
    No metrics available
Share - Bookmark