Aspects of Carbon Monoxide in Form of CO-Releasing Molecules Used in Cancer Treatment: More Light on the Way
Jiang, Wen G.
- Publisher: Hindawi Publishing Corporation
Oxidative Medicine and Cellular Longevity,
(issn: 1942-0900, eissn: 1942-0994)
Cytology | Review Article | QH573-671 | Article Subject | R1
Carbon monoxide (CO) has always been recognised as a toxic gas, due to its higher affinity for haemoglobin than oxygen.\ud However, biological studies have revealed an intriguing role for CO as an endogenous signalling molecule, a gasotransmitter. CO is\ud demonstrated to exertmany cellular activities including anti-inflammatory, antiapoptotic, and antiproliferative activities. In animal\ud studies, CO gas administration can prevent tissues from hypoxia or ischemic-reperfusion injury. As a result, there are a plethora\ud of reports dealing with the biological applications of CO and CO-releasing molecules (CORMs) in inflammatory and vascular\ud diseases. CORMs have already been tested as a therapeutic agent in clinical trials. More recently, an increased interest has been\ud drawn to CO’s potential use as an anticancer agent. In this review, we will aim to give an overview of the research focused on the\ud role of COand CORMs in different types of cancer and expand to the recent development of the next generation CORMs for clinical\ud application in cancer treatment.